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S1PR2 [plasma membrane]
Stable Identifier
R-HSA-419419
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Sphingosine 1-phosphate receptor 2, S1PR2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR2 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Lysosphingolipid and LPA receptors (Homo sapiens)
S1PR2-5 bind S1P (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR2 [plasma membrane] (Homo sapiens)
S1PR2-5:S1P [plasma membrane] (Homo sapiens)
S1PR2-5 [plasma membrane] (Homo sapiens)
S1PR2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95136 S1PR2
Gene Names
S1PR2, EDG5
Chain
chain:1-353
Reference Genes
BioGPS Gene:9294 S1PR2
COSMIC (genes):S1PR2 S1PR2
CTD Gene:9294 S1PR2
dbSNP Gene:9294 S1PR2
ENSEMBL:ENSG00000267534 S1PR2
HGNC:3169 S1PR2
KEGG:hsa:9294 S1PR2
Monarch:9294 S1PR2
NCBI Gene:9294 S1PR2
OMIM:605111 S1PR2
UCSC:O95136 S1PR2
Reference Transcript
RefSeq:NM_004230.3 S1PR2
Other Identifiers
11725795_at
11725796_x_at
16868619
208537_PM_at
208537_at
227684_PM_at
227684_at
34086_at
3850169
3850170
3850171
3850172
3850173
3850174
3850175
3850176
3850177
3850179
47156_at
8033956
9294
A_23_P16089
A_32_P827528
GE81364
GE821875
GO:0001664
GO:0003376
GO:0004930
GO:0005178
GO:0005515
GO:0005737
GO:0005886
GO:0007165
GO:0007186
GO:0007189
GO:0008284
GO:0008289
GO:0008528
GO:0016020
GO:0030036
GO:0038036
GO:0046847
GO:0060079
GO:0090394
GO:0098793
GO:0098794
GO:0098978
GO:0150052
GO:1903142
HMNXSV003042518
Hs.9016.0.A1_3p_at
ILMN_1812452
PH_hs_0006458
PH_hs_0025226
TC19001160.hg
g4758239_3p_at
Participates
as a member of
S1PR2-5 [plasma membrane] (Homo sapiens)
Inferred To
S1pr2 [plasma membrane]
(Mus musculus)
S1pr2 [plasma membrane]
(Rattus norvegicus)
s1pr2 [plasma membrane]
(Danio rerio)
s1pr2 [plasma membrane]
(Xenopus tropicalis)
S1PR2 [plasma membrane]
(Bos taurus)
S1PR2 [plasma membrane]
(Canis familiaris)
S1PR2 [plasma membrane]
(Gallus gallus)
S1PR2 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_004221.3
Guide to Pharmacology - Targets
276
ENSEMBL
ENST00000646641
,
ENSG00000267534
,
ENSP00000496438
OpenTargets
ENSG00000267534
ZINC - Substances
S1PR2_HUMAN
ZINC - Biogenic
S1PR2_HUMAN
ZINC target
O95136
PRO
O95136
GlyGen
O95136
PDB
7T6B
ZINC - Metabolites
S1PR2_HUMAN
GeneCards
S1PR2
HPA
ENSG00000267534-S1PR2
Pharos - Targets
O95136
Orphanet
S1PR2
ZINC - Predictions - Purchasable
S1PR2_HUMAN
HMDB Protein
HMDBP02604
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NWM8 FKBP14
1
FKBP14 [endoplasmic reticulum lumen]
(R-HSA-535607)
0.527
2
UniProt:O75915 ARL6IP5
1
ARL6IP5 [cytosol]
(R-HSA-2980942)
0.527
2
UniProt:Q92597 NDRG1
1
NDRG1 [cytosol]
(R-HSA-5628834)
0.527
2
UniProt:P17677 GAP43
2
PALM-C3,4-GAP43 [plasma membrane]
(R-HSA-8933482)
GAP43 [plasma membrane]
(R-HSA-452888)
0.527
2
UniProt:P06576 ATP5F1B
6
ATP5B(1-529) [cytosol]
(R-HSA-1267973)
ATP5B(1-529) [mitochondrial intermembrane space]
(R-HSA-1267985)
ATP5B(1-529) [mitochondrial inner membrane]
(R-HSA-1299440)
ATP5B(1-47) [mitochondrial matrix]
(R-HSA-8986172)
ATP5B [mitochondrial inner membrane]
(R-HSA-1299441)
ATP5F1B [mitochondrial matrix]
(R-HSA-164576)
0.527
2
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