Reactome | PALM-C3,4-GAP43 [plasma membrane]

PALM-C3,4-GAP43 [plasma membrane]

Stable Identifier

R-HSA-8933482

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

GAP43 (NEUM), Neuromodulin, NEUM_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P17677 GAP43

Gene Names

GAP43

Chain

chain:1-238

Reference Genes

BioGPS Gene:2596 GAP43

COSMIC (genes):GAP43 GAP43

CTD Gene:2596 GAP43

dbSNP Gene:2596 GAP43

ENSEMBL:ENSG00000172020 GAP43

HGNC:4140 GAP43

Monarch:2596 GAP43

NCBI Gene:2596 GAP43

OMIM:162060 GAP43

UCSC:P17677 GAP43

Reference Transcript

Other Identifiers

11740999_a_at

11741000_x_at

11744158_s_at

11754022_s_at

16944251

204471_PM_at

204471_at

216963_PM_s_at

216963_s_at

2596

2637144

2637145

2637146

2637158

2637161

2637162

2637163

2637173

2637174

2637175

2637176

37714_at

8081810

A_14_P107946

GE57885

GO:0001786

GO:0005515

GO:0005516

GO:0005737

GO:0005886

GO:0007200

GO:0007399

GO:0007411

GO:0008289

GO:0009611

GO:0010996

GO:0014069

GO:0016198

GO:0030154

GO:0030424

GO:0030425

GO:0031103

GO:0031527

GO:0032584

GO:0035727

GO:0040008

GO:0042246

GO:0042995

GO:0043204

GO:0043226

GO:0045165

GO:0045202

GO:0048708

GO:0048856

GO:0051489

GO:0060019

GO:0071944

GO:0098793

GO:0098982

GO:0099150

GO:1901981

HMNXSV003015378

Hs.79000.1.S1_3p_a_at

ILMN_1794552

M25667_at

PH_hs_0004558

S66541_s_at

TC03000595.hg

g4503910_3p_at

Participates

as an input of

LYPLA2 hydrolyses PALM-C3,4-GAP43 (Homo sapiens)

Other forms of this molecule

GAP43 [plasma membrane]

Inferred To

Gap43 [plasma membrane] (Mus musculus)

Gap43 [plasma membrane] (Rattus norvegicus)

gap43 [plasma membrane] (Danio rerio)

LOC119880636 [plasma membrane] (Canis familiaris)

PALM-C3,4-GAP43 [plasma membrane] (Gallus gallus)

GAP43 [plasma membrane] (Bos taurus)

GAP43 [plasma membrane] (Sus scrofa)

Modified Residues

Name

S-palmitoyl-L-cysteine at 3

Coordinate

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Name

S-palmitoyl-L-cysteine at 4

Coordinate

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Cross References

ENSEMBL

ENST00000393780, ENST00000305124, ENSP00000377372, ENSP00000305010

OpenTargets

ENSG00000172020

HPA

ENSG00000172020-GAP43

PRO

P17677

Pharos - Targets

P17677

GlyGen

P17677

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q05655 PRKCD	12	PRKCD [cytosol] (R-HSA-58200) PRKCD(1-329) [cytosol] (R-HSA-212547) PRKCD(330-676) [cytosol] (R-HSA-212551) p-T507,S645,S664-PRKCD(1-676) [plasma membrane] (R-HSA-198294) active p-T507,S645,S664-PRKCD [plasma membrane] (R-HSA-5607635) p-T507,S645,S664-PRKCD [cytosol] (R-HSA-5218734) p-T507-PRKCD [cytosol] (R-HSA-5218746) PRKCD(330-676) [azurophil granule lumen] (R-HSA-6799221) PRKCD(1-329) [azurophil granule lumen] (R-HSA-6799219) PRKCD(1-329) [extracellular region] (R-HSA-6806226) PRKCD(330-676) [extracellular region] (R-HSA-6806199) PRKCD(1-676) [nucleoplasm] (R-HSA-450606)	0.602	4
UniProt:P21917 DRD4	1	DRD4 [plasma membrane] (R-HSA-390809)	0.556	3
UniProt:Q13490 BIRC2	5	BIRC2 [cytosol] (R-HSA-50847) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2(373-618) [cytosol] (R-HSA-202931) BIRC2(1-372) [cytosol] (R-HSA-202913) K63polyUb-BIRC2 [cytosol] (R-HSA-5668512)	0.527	2
UniProt:Q8N5S1 S2541			0.527	2
UniProt:Q9UN70 PCDGK			0.527	2
UniProt:P32246 CCR1	1	CCR1 [plasma membrane] (R-HSA-373107)	0.527	2
UniProt:Q53EQ6 TIGD5			0.527	2
UniProt:O95136 S1PR2	1	S1PR2 [plasma membrane] (R-HSA-419419)	0.527	2
UniProt:Q96S94 CCNL2			0.527	2
UniProt:Q13503 MED21	1	MED21 [nucleoplasm] (R-HSA-212456)	0.527	2
UniProt:Q16822 PCK2	1	PCK2 [mitochondrial matrix] (R-HSA-372815)	0.527	2
UniProt:Q6PEY0 GJB7	1	GJB7 [endoplasmic reticulum membrane] (R-HSA-190639)	0.527	2
UniProt:Q8NFB2 T185A			0.527	2
UniProt:Q8N4S9 MALD2			0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:Q92845 KIFAP3	3	KIFAP3 [cytosol] (R-HSA-984736) KIFAP3 [cilium] (R-HSA-5624882) KIFAP3 [ciliary tip] (R-HSA-5625382)	0.527	2
UniProt:P05067-8 APP			0.499	3

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