Reactome | CYSLTR2 [plasma membrane]

CYSLTR2 [plasma membrane]

Stable Identifier

R-HSA-416399

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Cysteinyl leukotriene receptor 2, CLTR2_HUMAN

Locations in the PathwayBrowser for interactor UniProt:Q9NUP9 LIN7C

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Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Eicosanoid ligand-binding receptors (Homo sapiens)
        
        Leukotriene receptors (Homo sapiens)
        
        CYSLT2 binds LTC4,LTD4,LTE4 (Homo sapiens)
        
        CYSLTR2 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NS75 CYSLTR2

Gene Names

CYSLTR2, CYSLT2, CYSLT2R, PSEC0146

Chain

chain:1-346

Reference Genes

BioGPS Gene:57105 CYSLTR2

COSMIC - genes:CYSLTR2 CYSLTR2

CTD Gene:57105 CYSLTR2

dbSNP Gene:57105 CYSLTR2

ENSEMBL:ENSG00000152207 CYSLTR2

HGNC:18274 CYSLTR2

KEGG:hsa:57105 CYSLTR2

Monarch:57105 CYSLTR2

NCBI Gene:57105 CYSLTR2

OMIM:605666 CYSLTR2

UCSC:Q9NS75 CYSLTR2

Reference Transcript

Other Identifiers

11734945_at

11748485_s_at

11751390_a_at

16774724

220813_PM_at

220813_at

3489139

3489142

3489143

3489145

3489146

3489148

3489149

3489150

3489151

3489152

3489153

3489154

3489155

3489156

57105

7969050

A_14_P114786

A_14_P133033

A_23_P319466

GE87344

GO:0001631

GO:0002376

GO:0004930

GO:0004966

GO:0004974

GO:0005515

GO:0005886

GO:0006955

GO:0007165

GO:0007186

GO:0007218

GO:0016020

GO:0061737

HMNXSV003027993

ILMN_1773204

PH_hs_0013381

TC13000191.hg

g9966850_3p_at

Participates

as an input of

CYSLT2 binds LTC4,LTD4,LTE4 (Homo sapiens)

as a member of

as a component of

CYSLTR2:LTC4,LTD4,LTE4 [plasma membrane] (Homo sapiens)

Inferred To

AstA-R2 [plasma membrane] (Drosophila melanogaster)

cysltr1 [plasma membrane] (Danio rerio)

Homologues of CYSLTR2 [plasma membrane] (Caenorhabditis elegans)

npr-14 [plasma membrane] (Caenorhabditis elegans)

npr-21 [plasma membrane] (Caenorhabditis elegans)

Cysltr2 [plasma membrane] (Mus musculus)

Cysltr2 [plasma membrane] (Rattus norvegicus)

CYSLTR2 [plasma membrane] (Bos taurus)

CYSLTR2 [plasma membrane] (Caenorhabditis elegans)

CYSLTR2 [plasma membrane] (Canis familiaris)

CYSLTR2 [plasma membrane] (Gallus gallus)

npr-27 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001295400.1, NP_001295405.1, NP_001295394.1, NP_001295399.1, NP_065110.1, NP_001373941.1, NP_001373943.1, NP_001373942.1, NP_001295397.1, NP_001295398.1, NP_001295396.1

Guide to Pharmacology - Targets

270

OpenTargets

ENSG00000152207

ENSEMBL

ENST00000282018, ENSP00000477930, ENSG00000152207, ENST00000682523, ENSP00000508181, ENST00000614739, ENSP00000282018

ZINC - Substances

CLTR2_HUMAN

ZINC target

Q9NS75

PRO

Q9NS75

GlyGen

Q9NS75

PDB

9IXX, 9JH6, 9JH5

HPA

ENSG00000152207-CYSLTR2

GeneCards

CYSLTR2

Pharos - Targets

Q9NS75

Orphanet

CYSLTR2

ZINC - Predictions - Purchasable

CLTR2_HUMAN

HMDB Protein

HMDBP02368

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12959 DLG1	4	DLG1 [plasma membrane] (R-HSA-375977) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593) DLG1 [cytosol] (R-HSA-416332)	0.836	10
UniProt:P78352 DLG4	3	DLG4 [plasma membrane] (R-HSA-202135) DLG4 [endocytic vesicle membrane] (R-HSA-416847) DLG4 [cytosol] (R-HSA-6794267)	0.715	6
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.715	9
UniProt:Q92796 DLG3	2	DLG3 [plasma membrane] (R-HSA-443609) DLG3 [cytosol] (R-HSA-6794232)	0.623	4
UniProt:Q13884 SNTB1	1	SNTB1 [plasma membrane] (R-HSA-5490333)	0.623	2
UniProt:Q5T2W1 NHRF3			0.623	3
UniProt:Q13424 SNTA1	1	SNTA1 [plasma membrane] (R-HSA-5490334)	0.623	2
UniProt:O75970 MPDZ			0.623	14
UniProt:Q96QZ7 MAGI1			0.623	7
UniProt:Q6ZMN7 PZRN4			0.611	4
UniProt:Q86UL8 MAGI2	1	MAGI2 [cytosol] (R-HSA-451399)	0.611	7
UniProt:Q6P0Q8 MAST2			0.611	3
UniProt:O14936 CASK	1	CASK [cytosol] (R-HSA-373631)	0.59	2
UniProt:Q9NUP9 LIN7C	2	LIN7C [plasma membrane] (R-HSA-5216165) LIN7C [transport vesicle membrane] (R-HSA-9610411)	0.59	2
UniProt:Q5T2T1 MPP7	1	MPP7 [plasma membrane] (R-HSA-9714466)	0.59	2
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:Q9Y271 CYSLTR1	1	CYSLTR1 [plasma membrane] (R-HSA-416418)	0.471	2
UniProt:O60895 RAMP2	1	RAMP2 [plasma membrane] (R-HSA-420200)	0.471	4

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