CysLT receptors can bind cysteinyl leukotrienes

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The cysteinyl-leukotrienes (cys-LTs) are potent smooth muscle contractile agents mediating bronchoconstriction. Examples are LTC4, LTD4 and LTE4. There are two human cys-LT receptors, 1 (Lynch KR et al, 1999) and 2 (Heise CE et al, 2000). They mediate their effects via coupling to the G protein alpha q/11 subunit (Sarau HM et al, 1999).

Literature References
PubMed ID Title Journal Year
10851239 Characterization of the human cysteinyl leukotriene 2 receptor

Heise, CE, O'Dowd, BF, Figueroa, DJ, Sawyer, N, Nguyen, T, Im, DS, Stocco, R, Bellefeuille, JN, Abramovitz, M, Cheng, R, Williams DL, Jr, Zeng, Z, Liu, Q, Ma, L, Clements, MK, Coulombe, N, Liu, Y, Austin, CP, George, SR, O'Neill, GP, Metters, KM, Lynch, KR, Evans, JF

J Biol Chem 2000
10462554 Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor

Sarau, HM, Ames, RS, Chambers, J, Ellis, C, Elshourbagy, N, Foley, JJ, Schmidt, DB, Muccitelli, RM, Jenkins, O, Murdock, PR, Herrity, NC, Halsey, W, Sathe, G, Muir, AI, Nuthulaganti, P, Dytko, GM, Buckley, PT, Wilson, S, Bergsma, DJ, Hay, DW

Mol Pharmacol 1999
10391245 Characterization of the human cysteinyl leukotriene CysLT1 receptor

Lynch, KR, O'Neill, GP, Liu, Q, Im, DS, Sawyer, N, Metters, KM, Coulombe, N, Abramovitz, M, Figueroa, DJ, Zeng, Z, Connolly, BM, Bai, C, Austin, CP, Chateauneuf, A, Stocco, R, Greig, GM, Kargman, S, Hooks, SB, Hosfield, E, Williams DL, Jr, Ford-Hutchinson, AW, Caskey, CT, Evans, JF

Nature 1999
Participant Of
Orthologous Events
Cite Us!