CYSLT2 binds LTC4,LTD4,LTE4

Stable Identifier
R-HSA-391943
Type
Reaction [binding]
Species
Homo sapiens
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The cysteinyl-leukotrienes are potent smooth muscle contractile agents mediating bronchoconstriction. Examples are LTC4, LTD4 and LTE4. There are two human cysteinyl-leukotriene receptors, CYSLTR1 and CYSLTR2 (Heise et al. 2000). They mediate their effects via coupling to the G protein alpha q/11 subunit (Sarau et al. 1999).

Literature References
PubMed ID Title Journal Year
10851239 Characterization of the human cysteinyl leukotriene 2 receptor

Heise, CE, O'Dowd, BF, Figueroa, DJ, Sawyer, N, Nguyen, T, Im, DS, Stocco, R, Bellefeuille, JN, Abramovitz, M, Cheng, R, Williams DL, Jr, Zeng, Z, Liu, Q, Ma, L, Clements, MK, Coulombe, N, Liu, Y, Austin, CP, George, SR, O'Neill, GP, Metters, KM, Lynch, KR, Evans, JF

J Biol Chem 2000
10462554 Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor

Sarau, HM, Ames, RS, Chambers, J, Ellis, C, Elshourbagy, N, Foley, JJ, Schmidt, DB, Muccitelli, RM, Jenkins, O, Murdock, PR, Herrity, NC, Halsey, W, Sathe, G, Muir, AI, Nuthulaganti, P, Dytko, GM, Buckley, PT, Wilson, S, Bergsma, DJ, Hay, DW

Mol Pharmacol 1999
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