Reactome | DLG3 [cytosol]

DLG3 [cytosol]

Stable Identifier

R-HSA-6794232

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

SAP-102, Disks large homolog 3, DLG3_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Protein-protein interactions at synapses (Homo sapiens)
  - Neurexins and neuroligins (Homo sapiens)
    - ABP1 binds SHANK proteins (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG3 [cytosol] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:DBNL [cytosol] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG3 [cytosol] (Homo sapiens)
    - BEGAIN binds DLG2,DLG3,DLG4 (Homo sapiens)
      - NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG3 [cytosol] (Homo sapiens)
      - NMDA receptor complex:PSD-95:BEGAIN [plasma membrane] (Homo sapiens)
        
        NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG3 [cytosol] (Homo sapiens)
    - GKAPs bind PSD-95 members (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG3 [cytosol] (Homo sapiens)
      - NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG3 [cytosol] (Homo sapiens)
    - HOMER binds SHANK proteins (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG3 [cytosol] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3:2xHOMER1,2,3:GRM1,5 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG3 [cytosol] (Homo sapiens)
    - NLGNs binds PSD-95 subfamily members (Homo sapiens)
      - DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG3 [cytosol] (Homo sapiens)
      - NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG3 [cytosol] (Homo sapiens)
    - NMDA receptor complex:DLG2,DLG3,DLG4 binds SPAR (Homo sapiens)
      - NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG3 [cytosol] (Homo sapiens)
      - NMDA receptor complex:DLG2,DLG3,DLG4:SPAR [plasma membrane] (Homo sapiens)
        
        NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG3 [cytosol] (Homo sapiens)
    - NMDA receptor complex:DLG2,DLG3,DLG4:SPAR binds PDLIM5 (Homo sapiens)
      - NMDA receptor complex:DLG2,DLG3,DLG4:SPAR [plasma membrane] (Homo sapiens)
        
        NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG3 [cytosol] (Homo sapiens)
      - NMDA receptor complex:DLG2,DLG3,DLG4:SPAR:PDLIM5 [plasma membrane] (Homo sapiens)
        
        NMDA receptor complex:DLG2,DLG3,DLG4:SPAR [plasma membrane] (Homo sapiens)
        
        NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG3 [cytosol] (Homo sapiens)
    - NMDAR binds PSD-95 subfamily members (Homo sapiens)
      - DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG3 [cytosol] (Homo sapiens)
      - NMDA receptor complex:DLG2,DLG3,DLG4 [plasma membrane] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG3 [cytosol] (Homo sapiens)
    - SHANK proteins bind GKAPs (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG3 [cytosol] (Homo sapiens)
      - NRXNs:NLGN dimer:PSD-95:GKAP1-4:SHANK1,2,3 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimer:PSD-95:GKAP1-4 [plasma membrane] (Homo sapiens)
        
        NRXNs:NLGN dimers:PSD-95 members [cytosol] (Homo sapiens)
        
        DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)
        
        DLG3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92796 DLG3

Gene Names

DLG3, KIAA1232

Chain

initiator methionine:, chain:1-817

Reference Genes

BioGPS Gene:1741 DLG3

COSMIC (genes):DLG3 DLG3

CTD Gene:1741 DLG3

dbSNP Gene:1741 DLG3

ENSEMBL:ENSG00000082458 DLG3

ENSEMBL_homo_sapiens_GENE:ENSG00000082458.12 DLG3

HGNC:2902 DLG3

KEGG Gene (Homo sapiens):1741 DLG3

Monarch:1741 DLG3

NCBI Gene:1741 DLG3

OMIM:300189 DLG3

UCSC:Q92796 DLG3

Reference Transcript

Other Identifiers

11720593_s_at

11720594_a_at

11736598_a_at

11736599_a_at

11736600_s_at

17104540

1741

207732_PM_s_at

207732_s_at

212727_PM_at

212727_at

212728_PM_at

212728_at

212729_PM_at

212729_at

3980644

3980645

3980647

3980649

3980650

3980652

3980654

3980657

3980658

3980659

3980660

3980661

3980662

3980673

3980677

3980679

3980681

3980683

3980687

3980688

3980689

3980692

3980694

3980695

3980696

3980697

3980698

3980699

3980700

3980701

3980702

3980703

3980704

3980705

3980706

3980707

3980708

3980709

3980710

3980711

41453_at

43351_at

47413_at

8168179

A_14_P124375

A_24_P74731

A_24_P945283

GE522180

GE53840

GO:0001736

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0005912

GO:0005923

GO:0007155

GO:0007163

GO:0007268

GO:0008285

GO:0016323

GO:0019900

GO:0019902

GO:0023052

GO:0031594

GO:0031625

GO:0032281

GO:0036211

GO:0043005

GO:0043113

GO:0043226

GO:0045197

GO:0048856

GO:0061098

GO:0097120

GO:0098609

GO:0098839

GO:0098978

GO:0099072

HMNXSV003036638

Hs.11101.0.S1_3p_at

Hs.11101.0.S2_3p_at

Hs.11101.0.S3_3p_at

ILMN_1811515

ILMN_2255043

ILMN_2336728

PH_hs_0001083

TC0X000379.hg

U49089_at

g10863920_3p_s_at

Participates

as a member of

DLG2, DLG3, DLG4 [cytosol] (Homo sapiens)

Other forms of this molecule

DLG3 [plasma membrane]

Inferred To

dlg3 [cytosol] (Xenopus tropicalis)

dlg-1 [cytosol] (Caenorhabditis elegans)

Dlg3 [cytosol] (Mus musculus)

Dlg3 [cytosol] (Rattus norvegicus)

DLG3 [cytosol] (Bos taurus)

DLG3 [cytosol] (Canis familiaris)

DLG3 [cytosol] (Sus scrofa)

dlg1 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_065781.1, NP_001159750.1, XP_005262305.1, XP_016884815.1, NP_066943.2

OpenTargets

ENSG00000082458

HPA

ENSG00000082458-DLG3

GeneCards

Q92796

Ensembl

ENSP00000441393, ENSG00000082458, ENST00000374355, ENSP00000363480, ENST00000374360, ENSP00000363475, ENST00000542398

PRO

Q92796

Pharos - Targets

Q92796

Orphanet

17418

PDB

2I1N, 1UM7, 2FE5

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y2T3 GDA	1	GDA [cytosol] (R-HSA-56087)	0.644	6
UniProt:Q9P1A6-3 DLGAP2			0.556	3
UniProt:Q6IS01 Q6IS01			0.556	3
UniProt:Q15056-2 EIF4H			0.556	3
UniProt:Q9HB19 PLEKHA2	1	PLEKHA2 [plasma membrane] (R-HSA-8870329)	0.556	3
UniProt:P24390 KDELR1	4	KDELR1 [endoplasmic reticulum membrane] (R-HSA-6813886) KDELR1 [Golgi membrane] (R-HSA-6808781) KDELR1 [transport vesicle] (R-HSA-6808782) KDELR1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-6807760)	0.556	3
UniProt:P62241 RPS8	2	RPS8 [nucleoplasm] (R-HSA-6791203) RPS8 [cytosol] (R-HSA-72385)	0.556	3
UniProt:Q969R2-2 OSBP2			0.556	3
UniProt:P04004 VTN	1	VTN [extracellular region] (R-HSA-215971)	0.556	3
UniProt:Q6UWP2-2 DHRS11			0.556	3
UniProt:P62136 PPP1CA	1	PPP1CA [cytosol] (R-HSA-163525)	0.544	2

Cite Us!