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RAMP2 [plasma membrane]
Stable Identifier
R-HSA-420200
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Receptor activity-modifying protein 2, RAMP2_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to mechanical stimuli (Homo sapiens)
Response of endothelial cells to shear stress (Homo sapiens)
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
ADM (Adrenomedullin) binds CALCRL:RAMP2 (Homo sapiens)
ADM:CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
ADM:CALCRL:RAMP2 binds G(s):GDP:Gbeta:Ggamma heterotrimer (Homo sapiens)
ADM:CALCLR:RAMP2:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
ADM:CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
ADM:CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
ADM:CALCRL:RAMP2:G-alpha(s):GDP:G-beta:G-gamma exchanges GDP for GTP (Homo sapiens)
ADM:CALCLR:RAMP2:G-alpha(s):GDP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
ADM:CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
ADM:CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma dissociates (Homo sapiens)
ADM:CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
ADM:CALCRL:RAMP2:G-alpha(s):GTP:G-beta:G-gamma [plasma membrane] (Homo sapiens)
ADM:CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
AMY1-3:IAPP(34-70) [plasma membrane] (Homo sapiens)
AMY1-3 [plasma membrane] (Homo sapiens)
AMY2 receptor [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
Adrenomedullin receptor:ADM,ADM2 [plasma membrane] (Homo sapiens)
Adrenomedullin receptor [plasma membrane] (Homo sapiens)
CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
AMY1-3:IAPP(34-70) [plasma membrane] (Homo sapiens)
AMY1-3 [plasma membrane] (Homo sapiens)
AMY2 receptor [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
Adrenomedullin receptor:ADM,ADM2 [plasma membrane] (Homo sapiens)
Adrenomedullin receptor [plasma membrane] (Homo sapiens)
CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
AMY1-3:IAPP(34-70) [plasma membrane] (Homo sapiens)
AMY1-3 [plasma membrane] (Homo sapiens)
AMY2 receptor [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
Adrenomedullin receptor:ADM,ADM2 [plasma membrane] (Homo sapiens)
Adrenomedullin receptor [plasma membrane] (Homo sapiens)
CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
AMY1-3:IAPP(34-70) [plasma membrane] (Homo sapiens)
AMY1-3 [plasma membrane] (Homo sapiens)
AMY2 receptor [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
Adrenomedullin receptor:ADM,ADM2 [plasma membrane] (Homo sapiens)
Adrenomedullin receptor [plasma membrane] (Homo sapiens)
CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
AMY1-3:IAPP(34-70) [plasma membrane] (Homo sapiens)
AMY1-3 [plasma membrane] (Homo sapiens)
AMY2 receptor [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
Adrenomedullin receptor:ADM,ADM2 [plasma membrane] (Homo sapiens)
Adrenomedullin receptor [plasma membrane] (Homo sapiens)
CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
AMY1-3 [plasma membrane] (Homo sapiens)
AMY2 receptor [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
Adrenomedullin receptor [plasma membrane] (Homo sapiens)
CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
Calcitonin-like ligand receptors (Homo sapiens)
AMY1-3 bind IAPP(34-70) (Homo sapiens)
AMY1-3 [plasma membrane] (Homo sapiens)
AMY2 receptor [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
AMY1-3:IAPP(34-70) [plasma membrane] (Homo sapiens)
AMY1-3 [plasma membrane] (Homo sapiens)
AMY2 receptor [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
AMY1-3 bind pramlintide (Homo sapiens)
AMY1-3 [plasma membrane] (Homo sapiens)
AMY2 receptor [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
AMY1-3:pramlintide [plasma membrane] (Homo sapiens)
AMY1-3 [plasma membrane] (Homo sapiens)
AMY2 receptor [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
The adrenomedullin receptor can bind adrenomedullin and intermedin (Homo sapiens)
Adrenomedullin receptor [plasma membrane] (Homo sapiens)
CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
Adrenomedullin receptor:ADM,ADM2 [plasma membrane] (Homo sapiens)
Adrenomedullin receptor [plasma membrane] (Homo sapiens)
CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
RAMP2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60895 RAMP2
Gene Names
RAMP2
Chain
signal peptide:1-42, chain:43-175
Reference Genes
BioGPS Gene:10266 RAMP2
COSMIC (genes):RAMP2 RAMP2
CTD Gene:10266 RAMP2
dbSNP Gene:10266 RAMP2
ENSEMBL:ENSG00000131477 RAMP2
HGNC:9844 RAMP2
KEGG:hsa:10266 RAMP2
Monarch:10266 RAMP2
NCBI Gene:10266 RAMP2
OMIM:605154 RAMP2
UCSC:O60895 RAMP2
Reference Transcript
RefSeq:NM_005854.3 RAMP2
Other Identifiers
10266
11729325_a_at
16834436
205779_PM_at
205779_at
3722040
3722042
3722044
3722045
3722046
3722047
3722048
3722049
3722050
3722051
3722052
3722053
3722055
3722057
38177_at
8007348
A_14_P124151
A_24_P116710
GE55136
GO:0001525
GO:0001570
GO:0001605
GO:0002040
GO:0003013
GO:0005515
GO:0005737
GO:0005764
GO:0005773
GO:0005886
GO:0005905
GO:0006816
GO:0006886
GO:0007186
GO:0007189
GO:0007507
GO:0008217
GO:0008277
GO:0009986
GO:0010628
GO:0015026
GO:0015031
GO:0016020
GO:0016192
GO:0030154
GO:0030198
GO:0031623
GO:0032870
GO:0034330
GO:0034333
GO:0035924
GO:0043116
GO:0043226
GO:0043235
GO:0045766
GO:0048856
GO:0060089
GO:0070830
GO:0070831
GO:0072659
GO:0097084
GO:0150060
GO:1903143
GO:1990409
GO:1990410
GO:2000352
GO:2001214
HMNXSV003049630
ILMN_2149782
PH_hs_0009340
TC17000534.hg
g5032020_3p_at
Participates
as a component of
AMY2 receptor [plasma membrane] (Homo sapiens)
CALCRL:RAMP2 [plasma membrane] (Homo sapiens)
Inferred To
ramp2 [plasma membrane]
(Danio rerio)
Ramp2 [plasma membrane]
(Mus musculus)
Ramp2 [plasma membrane]
(Rattus norvegicus)
RAMP2 [plasma membrane]
(Bos taurus)
RAMP2 [plasma membrane]
(Canis familiaris)
RAMP2 [plasma membrane]
(Gallus gallus)
RAMP2 [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_005845.2
ENSEMBL
ENST00000587142
,
ENST00000253796
,
ENSP00000253796
,
ENSG00000131477
,
ENSP00000466455
OpenTargets
ENSG00000131477
GeneCards
RAMP2
HPA
ENSG00000131477-RAMP2
PRO
O60895
Pharos - Targets
O60895
GlyGen
O60895
HMDB Protein
HMDBP12700
PDB
6UUN
,
4RWF
,
3AQE
,
7TYH
,
2XVT
,
6V2E
,
7TYY
,
3AQF
,
7TYX
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