Reactome | SIRT2 [cytosol]

Stable Identifier

R-HSA-2161118

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NAD-dependent deacetylase sirtuin-2

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IXJ6 SIRT2

Gene Names

SIRT2, SIR2L, SIR2L2

Chain

initiator methionine:, chain:2-389

Reference Genes

COSMIC (genes):SIRT2 SIRT2

dbSNP Gene:22933 SIRT2

ENSEMBL:ENSG00000068903 SIRT2

Inferred To

SIRT2 [cytosol] (Bos taurus)

SIRT2 [cytosol] (Canis familiaris)

SIRT2 [cytosol] (Danio rerio)

SIRT2 [cytosol] (Drosophila melanogaster)

SIRT2 [cytosol] (Gallus gallus)

SIRT2 [cytosol] (Mus musculus)

SIRT2 [cytosol] (Rattus norvegicus)

SIRT2 [cytosol] (Sus scrofa)

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60566 BUB1B	1	BUB1B [cytosol] (R-HSA-141436)	0.576	3
UniProt:Q92831 KAT2B	1	KAT2B [nucleoplasm] (R-HSA-352430)	0.576	4
UniProt:P49591 SARS1	1	SARS [cytosol] (R-HSA-379691)	0.564	3
UniProt:Q04206 RELA	7	RELA [nucleoplasm] (R-HSA-177676) RELA [cytosol] (R-HSA-168172) p-S276-RELA [nucleoplasm] (R-HSA-5624468) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) p-S536-RELA [nucleoplasm] (R-HSA-9861499) MeK310-RELA [nucleoplasm] (R-HSA-8865233)	0.544	2
UniProt:P11413 G6PD	1	G6PD [cytosol] (R-HSA-70372)	0.524	3
UniProt:O60729 CDC14B	1	CDC14B [nucleoplasm] (R-HSA-3214897)	0.524	2
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.508	2
UniProt:Q9UBN7 HDAC6	4	HDAC6 [lysosomal lumen] (R-HSA-9660002) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589)	0.463	2
UniProt:P15172 MYOD1	1	MYOD1 [nucleoplasm] (R-HSA-445441)	0.462	2
UniProt:Q9UM11 FZR1	4	FZR1 [cytosol] (R-HSA-174249) FZR1 [nucleoplasm] (R-HSA-174099) p-FZR1 [nucleoplasm] (R-HSA-174257) p-FZR1 [cytosol] (R-HSA-174193)	0.462	2

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