Reactome | B-WICH recruits histone acetyltransferases

B-WICH recruits histone acetyltransferases

Stable Identifier

R-HSA-5250930

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

B-WICH recruits histone acetyltransferases

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Direct interactions between BAZ1B (WSTF) and histone acetyltransferases KAT2B, KAT2A, and EP300 are weak (Vintermist et al. 2011) so the acetyltransferases may interact with other subunits of B‑WICH or with proteins not in the B‑WICH complex. The ERCC6 (CSB) component of B‑WICH and MYOIC interact with KAT2B (PCAF) (Sarshad et al. 2013, Shen et al. 2013). The histone acetyltransferases are believed to acetylate histone H3 at lysine‑9 in rDNA since this modification is reduced in WSTF and MYOIC knockdown cells (Vintermist et al. 2011, Sarshad et al. 2013). Knockdown of KAT2B causes loss of acetylation on histone H4 and on histone H3 at lysine‑9 (Shen et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
21559432	The chromatin remodelling complex B-WICH changes the chromatin structure and recruits histone acetyl-transferases to active rRNA genes Böhm, S, Ostlund Farrants, AK, Sadeghifar, F, Mansén, A, Vintermist, A, Percipalle, P, Louvet, E	PLoS ONE	2011
23667505	The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation Lyu, G, Zhou, T, Zhu, Q, Shen, M, Zhang, F, Gao, Q, Ling, T, Zong, L, Xie, W, Tao, W	PLoS ONE	2013
23555303	Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression Böhm, S, Sarshad, A, Percipalle, P, Fomproix, N, Sadeghifar, F, Vintermist, A, Louvet, E, Al-Muzzaini, B, Östlund, AK, Mori, R	PLoS Genet.	2013