B-WICH recruits histone acetyltransferases

Stable Identifier
Reaction [binding]
Homo sapiens
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Direct interactions between BAZ1B (WSTF) and histone acetyltransferases KAT2B, KAT2A, and EP300 are weak (Vintermist et al. 2011) so the acetyltransferases may interact with other subunits of B‑WICH or with proteins not in the B‑WICH complex. The ERCC6 (CSB) component of B‑WICH and MYOIC interact with KAT2B (PCAF) (Sarshad et al. 2013, Shen et al. 2013). The histone acetyltransferases are believed to acetylate histone H3 at lysine‑9 in rDNA since this modification is reduced in WSTF and MYOIC knockdown cells (Vintermist et al. 2011, Sarshad et al. 2013). Knockdown of KAT2B causes loss of acetylation on histone H4 and on histone H3 at lysine‑9 (Shen et al. 2013).

Literature References
PubMed ID Title Journal Year
21559432 The chromatin remodelling complex B-WICH changes the chromatin structure and recruits histone acetyl-transferases to active rRNA genes

Böhm, S, Ostlund Farrants, AK, Sadeghifar, F, Mansén, A, Vintermist, A, Percipalle, P, Louvet, E

PLoS ONE 2011
23667505 The chromatin remodeling factor CSB recruits histone acetyltransferase PCAF to rRNA gene promoters in active state for transcription initiation

Lyu, G, Zhou, T, Zhu, Q, Shen, M, Zhang, F, Gao, Q, Ling, T, Zong, L, Xie, W, Tao, W

PLoS ONE 2013
23555303 Nuclear myosin 1c facilitates the chromatin modifications required to activate rRNA gene transcription and cell cycle progression

Böhm, S, Sarshad, A, Percipalle, P, Fomproix, N, Sadeghifar, F, Vintermist, A, Louvet, E, Al-Muzzaini, B, Östlund, AK, Mori, R

PLoS Genet. 2013
Orthologous Events
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