Reactome | TIMP1 [extracellular region]

TIMP1 [extracellular region]

Stable Identifier

R-HSA-349743

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Metalloproteinase inhibitor 1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P01033 TIMP1

Gene Names

TIMP1, CLGI, TIMP

Chain

signal peptide:1-23, chain:24-207

Reference Genes

BioGPS Gene:7076 TIMP1

COSMIC (genes):TIMP1 TIMP1

CTD Gene:7076 TIMP1

dbSNP Gene:7076 TIMP1

ENSEMBL:ENSG00000102265 TIMP1

HGNC:11820 TIMP1

KEGG:hsa:7076 TIMP1

Monarch:7076 TIMP1

NCBI Gene:7076 TIMP1

OMIM:305370 TIMP1

UCSC:P01033 TIMP1

Reference Transcript

RefSeq:NM_003254.2 TIMP1

Other Identifiers

11715359_a_at

11715360_x_at

11763761_a_at

1693_s_at

17103185

201666_PM_at

201666_at

3976342

3976343

3976345

3976346

3976348

3976349

3976350

3976351

3976352

3976353

3976354

3976355

3976356

3976357

3976358

3976359

7076

8167185

A_14_P124887

A_23_P62115

GE80207

GO:0002020

GO:0002248

GO:0005125

GO:0005515

GO:0005576

GO:0005581

GO:0005604

GO:0005615

GO:0005788

GO:0007165

GO:0008083

GO:0008191

GO:0008270

GO:0008284

GO:0009725

GO:0010951

GO:0030312

GO:0030414

GO:0031012

GO:0031093

GO:0034097

GO:0043066

GO:0043086

GO:0043226

GO:0043434

GO:0046872

GO:0048018

GO:0048856

GO:0051045

GO:0051216

GO:0070062

GO:0071492

GO:0098772

GO:1901164

GO:1901653

GO:1905049

GO:2001044

HMNXSV003056170

ILMN_1711566

PH_hs_0026117

TC0X000238.hg

g4507508_3p_s_at

Participates

as a member of

as a component of

proMMP9:TIMP1 [extracellular region] (Homo sapiens)

as an input of

proMMP9 binds TIMP1 (Homo sapiens)

This entity regulates

Negatively

TGFBR3_mem cleavage by MMPs (Homo sapiens)

Other forms of this molecule

p-TIMP1 [endoplasmic reticulum lumen]

TIMP1 [endoplasmic reticulum lumen]

TIMP1 [platelet alpha granule lumen]

Inferred To

Homologues of TIMP1 [extracellular region] (Caenorhabditis elegans)

Homologues of TIMP1 [extracellular region] (Danio rerio)

TIMP1 [extracellular region] (Bos taurus)

TIMP1 [extracellular region] (Caenorhabditis elegans)

TIMP1 [extracellular region] (Canis familiaris)

TIMP1 [extracellular region] (Danio rerio)

TIMP1 [extracellular region] (Drosophila melanogaster)

TIMP1 [extracellular region] (Mus musculus)

TIMP1 [extracellular region] (Rattus norvegicus)

TIMP1 [extracellular region] (Sus scrofa)

TIMP1 [extracellular region] (Xenopus tropicalis)

Cross References

ENSEMBL

ENST00000218388, ENSP00000218388, ENSG00000102265

OpenTargets

ENSG00000102265

GeneCards

TIMP1

HPA

ENSG00000102265-TIMP1

PRO

P01033

Pharos - Targets

P01033

PDB

1OO9, 6MAV, 7S7M, 7S7L, 3MA2, 6N9D, 3V96, 1UEA, 1D2B, 2J0T

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08962 CD63	3	CD63 [platelet dense granule membrane] (R-HSA-51683) CD63 [plasma membrane] (R-HSA-114583) CD63 [azurophil granule membrane] (R-HSA-6799157)	0.691	8
UniProt:P14780 MMP9	8	MMP9(107-707) [extracellular region] (R-HSA-668812) MMP9(20-707) [extracellular region] (R-HSA-1604376) MMP9(20-59) [extracellular region] (R-HSA-1604685) MMP9(60-707) [extracellular region] (R-HSA-1604726) MMP9(60-106) [extracellular region] (R-HSA-1604699) MMP9(20-106) [extracellular region] (R-HSA-1604713) MMP9 [ficolin-1-rich granule lumen] (R-HSA-6800973) MMP9 [tertiary granule lumen] (R-HSA-6800181)	0.644	4
UniProt:P27701 CD82			0.602	11
UniProt:P08833 IGFBP1	3	p-IGFBP1 [endoplasmic reticulum lumen] (R-HSA-8957029) IGFBP1 [endoplasmic reticulum lumen] (R-HSA-8956699) IGFBP1 [extracellular region] (R-HSA-381513)	0.527	2
UniProt:P21802 FGFR2	20	FGFR2 IIIa TM [extracellular region] (R-HSA-8851703) FGFR2 [plasma membrane] (R-HSA-2023840) FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane] (R-HSA-8853137) FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane] (R-HSA-8853154) FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane] (R-HSA-8853123) FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane] (R-HSA-8853158) FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane] (R-HSA-8853150) FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane] (R-HSA-8853153) FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane] (R-HSA-8853139) FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane] (R-HSA-8853159) FGFR2 N549H [plasma membrane] (R-HSA-2033296) FGFR2 N549K [plasma membrane] (R-HSA-1637910) FGFR2 K660N [plasma membrane] (R-HSA-1637905) p-8Y-FGFR2 K660M [plasma membrane] (R-HSA-2033300) p-8Y-FGFR2 K660E [plasma membrane] (R-HSA-2033298) phosphorylated FGFR2 L764Hfs*4 [plasma membrane] (R-HSA-2071957) p-8Y-FGFR2 W290C [plasma membrane] (R-HSA-2029875) p-8Y-FGFR2 S267P [plasma membrane] (R-HSA-2029879) p-8Y-FGFR2 [plasma membrane] (R-HSA-2029874) p-8Y-FGFR2 N549K [plasma membrane] (R-HSA-2033306)	0.527	2
UniProt:P09238 MMP10	2	MMP10(18-476) [extracellular region] (R-HSA-1604748) MMP10 [extracellular region] (R-HSA-1442488)	0.527	3
UniProt:P20908 COL5A1	20	3x4Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023553) 3x4Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023664) GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023513) GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023628) 3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023564) 3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023647) COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022460) 3x4Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022510) 3x4Hyp-3Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022483) 3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022948) 3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022970) 5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022989) 3x4Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268653) COL5A1(38-1838) [extracellular region] (R-HSA-2268703) 3x4Hyp-5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268718) 3x4Hyp-GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268664) 3x4Hyp-3Hyp-COL5A1(38-1838) [extracellular region] (R-HSA-2268667) GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268629) 5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268644) 3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268663)	0.508	2

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