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TIMP1 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-8956691
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
Metalloproteinase inhibitor 1, TIMP1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Post-translational protein phosphorylation (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
TIMP1 [endoplasmic reticulum lumen] (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
TIMP1 [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01033 TIMP1
Gene Names
TIMP1, CLGI, TIMP
Chain
signal peptide:1-23, chain:24-207
Reference Genes
BioGPS Gene:7076 TIMP1
COSMIC (genes):TIMP1 TIMP1
CTD Gene:7076 TIMP1
dbSNP Gene:7076 TIMP1
ENSEMBL:ENSG00000102265 TIMP1
HGNC:11820 TIMP1
KEGG:hsa:7076 TIMP1
Monarch:7076 TIMP1
NCBI Gene:7076 TIMP1
OMIM:305370 TIMP1
UCSC:P01033 TIMP1
Reference Transcript
RefSeq:NM_003254.2 TIMP1
Other Identifiers
11715359_a_at
11715360_x_at
11763761_a_at
1693_s_at
17103185
201666_PM_at
201666_at
3976342
3976343
3976345
3976346
3976348
3976349
3976350
3976351
3976352
3976353
3976354
3976355
3976356
3976357
3976358
3976359
7076
8167185
A_14_P124887
A_23_P62115
GE80207
GO:0002020
GO:0002248
GO:0005125
GO:0005515
GO:0005576
GO:0005581
GO:0005604
GO:0005615
GO:0005788
GO:0007165
GO:0008083
GO:0008191
GO:0008270
GO:0008284
GO:0009725
GO:0010951
GO:0030312
GO:0030414
GO:0031012
GO:0031093
GO:0034097
GO:0043066
GO:0043086
GO:0043226
GO:0043434
GO:0046872
GO:0048018
GO:0048856
GO:0051045
GO:0051216
GO:0070062
GO:0071492
GO:0098772
GO:1901164
GO:1901653
GO:1905049
GO:2001044
HMNXSV003056170
ILMN_1711566
PH_hs_0026117
TC0X000238.hg
g4507508_3p_s_at
Participates
as a member of
FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
Other forms of this molecule
TIMP1 [platelet alpha granule lumen]
p-TIMP1 [endoplasmic reticulum lumen]
TIMP1 [extracellular region]
Inferred To
TIMP1 [endoplasmic reticulum lumen]
(Bos taurus)
TIMP1 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
TIMP1 [endoplasmic reticulum lumen]
(Canis familiaris)
TIMP1 [endoplasmic reticulum lumen]
(Drosophila melanogaster)
TIMP1 [endoplasmic reticulum lumen]
(Mus musculus)
TIMP1 [endoplasmic reticulum lumen]
(Rattus norvegicus)
TIMP1 [endoplasmic reticulum lumen]
(Sus scrofa)
TIMP1 [endoplasmic reticulum lumen]
(Xenopus tropicalis)
Homologues of TIMP1 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_003245.1
ENSEMBL
ENSP00000218388
,
ENST00000218388
OpenTargets
ENSG00000102265
HPA
ENSG00000102265-TIMP1
PRO
P01033
Pharos - Targets
P01033
PDB
7S7M
,
1D2B
,
3V96
,
1OO9
,
2J0T
,
1UEA
,
6MAV
,
7S7L
,
3MA2
,
6N9D
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08962 CD63
3
CD63 [platelet dense granule membrane]
(R-HSA-51683)
CD63 [plasma membrane]
(R-HSA-114583)
CD63 [azurophil granule membrane]
(R-HSA-6799157)
0.691
8
UniProt:P14780 MMP9
8
MMP9(107-707) [extracellular region]
(R-HSA-668812)
MMP9(20-707) [extracellular region]
(R-HSA-1604376)
MMP9(20-106) [extracellular region]
(R-HSA-1604713)
MMP9(20-59) [extracellular region]
(R-HSA-1604685)
MMP9(60-707) [extracellular region]
(R-HSA-1604726)
MMP9(60-106) [extracellular region]
(R-HSA-1604699)
MMP9 [tertiary granule lumen]
(R-HSA-6800181)
MMP9 [ficolin-1-rich granule lumen]
(R-HSA-6800973)
0.644
4
UniProt:P27701 CD82
0.602
11
UniProt:P08833 IGFBP1
3
IGFBP1 [extracellular region]
(R-HSA-381513)
p-IGFBP1 [endoplasmic reticulum lumen]
(R-HSA-8957029)
IGFBP1 [endoplasmic reticulum lumen]
(R-HSA-8956699)
0.527
2
UniProt:P09238 MMP10
2
MMP10(18-476) [extracellular region]
(R-HSA-1604748)
MMP10 [extracellular region]
(R-HSA-1442488)
0.527
3
UniProt:P21802 FGFR2
20
FGFR2 IIIa TM [extracellular region]
(R-HSA-8851703)
FGFR2 [plasma membrane]
(R-HSA-2023840)
FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
(R-HSA-8853137)
FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane]
(R-HSA-8853154)
FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane]
(R-HSA-8853123)
FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane]
(R-HSA-8853158)
FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane]
(R-HSA-8853150)
FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane]
(R-HSA-8853153)
FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane]
(R-HSA-8853139)
FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane]
(R-HSA-8853159)
FGFR2 N549H [plasma membrane]
(R-HSA-2033296)
FGFR2 N549K [plasma membrane]
(R-HSA-1637910)
FGFR2 K660N [plasma membrane]
(R-HSA-1637905)
p-8Y-FGFR2 K660M [plasma membrane]
(R-HSA-2033300)
p-8Y-FGFR2 K660E [plasma membrane]
(R-HSA-2033298)
phosphorylated FGFR2 L764Hfs*4 [plasma membrane]
(R-HSA-2071957)
p-8Y-FGFR2 W290C [plasma membrane]
(R-HSA-2029875)
p-8Y-FGFR2 S267P [plasma membrane]
(R-HSA-2029879)
p-8Y-FGFR2 [plasma membrane]
(R-HSA-2029874)
p-8Y-FGFR2 N549K [plasma membrane]
(R-HSA-2033306)
0.527
2
UniProt:P20908 COL5A1
20
3x4Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023553)
3x4Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023664)
GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023513)
GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023628)
3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023564)
3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023647)
COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022460)
3x4Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022510)
3x4Hyp-3Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022483)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022948)
3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022970)
5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022989)
3x4Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268653)
COL5A1(38-1838) [extracellular region]
(R-HSA-2268703)
3x4Hyp-5Hyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268718)
3x4Hyp-GalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268664)
3x4Hyp-3Hyp-COL5A1(38-1838) [extracellular region]
(R-HSA-2268667)
GalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268629)
5Hyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268644)
3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268663)
0.508
2
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