Reactome | MMP9(60-707) [extracellular region]

MMP9(60-707) [extracellular region]

Stable Identifier

R-HSA-1604726

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

proMMP9 intermediate form, Pro Matrix metalloproteinase-9 (MMP9), MMP9_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P14780 MMP9

Gene Names

MMP9, CLG4B

Chain

signal peptide:1-19, propeptide:20-93, chain:94-, chain:107-707, propeptide:-707

Reference Genes

BioGPS Gene:4318 MMP9

COSMIC (genes):MMP9 MMP9

CTD Gene:4318 MMP9

dbSNP Gene:4318 MMP9

ENSEMBL:ENSG00000100985 MMP9

ENSEMBL_homo_sapiens_GENE:ENSG00000100985.7 MMP9

HGNC:7176 MMP9

KEGG Gene (Homo sapiens):4318 MMP9

Monarch:4318 MMP9

NCBI Gene:4318 MMP9

OMIM:120361 MMP9

UCSC:P14780 MMP9

Reference Transcript

RefSeq:NM_004994.2 MMP9

Other Identifiers

11719657_a_at

16914395

203936_PM_s_at

203936_s_at

31859_at

3887212

3887213

3887214

3887215

3887216

3887217

3887218

3887219

3887220

3887221

3887222

3887223

3887224

3887226

3887227

3887228

3887229

3887230

4318

8063115

A_14_P117083

A_23_P40174

GE57525

GO:0001501

GO:0001934

GO:0003824

GO:0004175

GO:0004222

GO:0004252

GO:0005515

GO:0005518

GO:0005576

GO:0005615

GO:0006508

GO:0006915

GO:0006954

GO:0007005

GO:0007566

GO:0008233

GO:0008237

GO:0008270

GO:0012501

GO:0016477

GO:0016787

GO:0022414

GO:0022617

GO:0023052

GO:0030154

GO:0030198

GO:0030225

GO:0030312

GO:0030574

GO:0031012

GO:0031410

GO:0034614

GO:0035987

GO:0036211

GO:0042802

GO:0043065

GO:0043066

GO:0043226

GO:0043388

GO:0045742

GO:0046872

GO:0048013

GO:0048856

GO:0048870

GO:0050896

GO:0051549

GO:0055085

GO:0062023

GO:0070062

GO:0071222

GO:0071276

GO:0071492

GO:0090200

GO:0140096

GO:0150077

GO:1900122

GO:1904645

GO:1904707

GO:1904724

GO:1904813

GO:2000697

GO:2001243

GO:2001258

GO:2001268

HMNXSV003043897

ILMN_1796316

J05070_at

PH_hs_0009143

TC20000363.hg

g4826835_3p_s_at

Participates

as an input of

Activation of MMP9 intermediate form by MMPs (Homo sapiens)

as an output of

Initial activation of proMMP9 by MMPs (Homo sapiens)

Other forms of this molecule

MMP9 [tertiary granule lumen]

MMP9 [ficolin-1-rich granule lumen]

MMP9(60-106) [extracellular region]

MMP9(20-59) [extracellular region]

MMP9(20-106) [extracellular region]

MMP9(20-707) [extracellular region]

MMP9(107-707) [extracellular region]

Inferred To

Homologues of MMP9(60-707) [extracellular region] (Caenorhabditis elegans)

Homologues of MMP9(60-707) [extracellular region] (Drosophila melanogaster)

MMP9(60-707) [extracellular region] (Bos taurus)

MMP9(60-707) [extracellular region] (Caenorhabditis elegans)

MMP9(60-707) [extracellular region] (Canis familiaris)

MMP9(60-707) [extracellular region] (Danio rerio)

MMP9(60-707) [extracellular region] (Drosophila melanogaster)

MMP9(60-707) [extracellular region] (Gallus gallus)

MMP9(60-707) [extracellular region] (Mus musculus)

MMP9(60-707) [extracellular region] (Rattus norvegicus)

MMP9(60-707) [extracellular region] (Sus scrofa)

MMP9(60-707) [extracellular region] (Xenopus tropicalis)

Cross References

RefSeq

NP_004985.2

ZINC - World Drugs

MMP9_HUMAN

Guide to Pharmacology - Targets

1633

OpenTargets

ENSG00000100985

ZINC - FDA approved

MMP9_HUMAN

ZINC - Substances

MMP9_HUMAN

ZINC - Biogenic

MMP9_HUMAN

ZINC target

P14780

PRO

P14780

PDB

4H1Q, 4XCT, 6ESM, 2OW2, 8K5X, 1GKC, 5CUH, 8K5Y, 5TH9, 1ITV, 2OW1, 4HMA, 2OVZ, 2OW0, 2OVX, 5TH6, 5UE4, 4H2E, 5UE3, 4H82, 4H3X, 4JIJ, 5I12, 8K5V, 1L6J, 8K5W, 4WZV, 4JQG, 1GKD

ZINC - Investigational

MMP9_HUMAN

ZINC - Metabolites

MMP9_HUMAN

HPA

ENSG00000100985-MMP9

GeneCards

P14780

Ensembl

ENST00000372330, ENSG00000100985, ENSP00000361405

Pharos - Targets

P14780

Orphanet

18601

ZINC - Predictions - Purchasable

MMP9_HUMAN

HMDB Protein

HMDBP02128

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P14780 MMP9	8	MMP9 [tertiary granule lumen] (R-HSA-6800181) MMP9 [ficolin-1-rich granule lumen] (R-HSA-6800973) MMP9(60-106) [extracellular region] (R-HSA-1604699) MMP9(60-707) [extracellular region] (R-HSA-1604726) MMP9(20-59) [extracellular region] (R-HSA-1604685) MMP9(20-106) [extracellular region] (R-HSA-1604713) MMP9(20-707) [extracellular region] (R-HSA-1604376) MMP9(107-707) [extracellular region] (R-HSA-668812)	0.761	4
UniProt:P01033 TIMP1	4	TIMP1 [platelet alpha granule lumen] (R-HSA-349745) TIMP1 [extracellular region] (R-HSA-349743) p-TIMP1 [endoplasmic reticulum lumen] (R-HSA-8957082) TIMP1 [endoplasmic reticulum lumen] (R-HSA-8956691)	0.644	4
UniProt:P13611 VCAN	20	D2,4,4(S)3-VCAN [lysosomal lumen] (R-HSA-2065151) D2,4(S)2-VCAN [lysosomal lumen] (R-HSA-2065232) D4S-VCAN [lysosomal lumen] (R-HSA-2065238) VCAN [lysosomal lumen] (R-HSA-2065229) CSE-VCAN [lysosomal lumen] (R-HSA-2065061) C6S-VCAN [lysosomal lumen] (R-HSA-2065142) C4S-VCAN [lysosomal lumen] (R-HSA-2065149) CSE-VCAN [extracellular region] (R-HSA-2063966) C6S-VCAN [extracellular region] (R-HSA-2063978) C4S-VCAN [extracellular region] (R-HSA-2064142) CSE-VCAN [Golgi lumen] (R-HSA-2064028) C6S-VCAN [Golgi lumen] (R-HSA-2063999) D4S-VCAN [extracellular region] (R-HSA-2065268) D2,4(S)2-VCAN [extracellular region] (R-HSA-2065255) D2,4,4(S)3-VCAN [extracellular region] (R-HSA-2065103) chondroitin(1)-VCAN [Golgi lumen] (R-HSA-2064218) chondroitin(2)-VCAN [Golgi lumen] (R-HSA-2063990) C4S-VCAN [Golgi lumen] (R-HSA-2064162) chondroitin(3)-VCAN [Golgi lumen] (R-HSA-2064169) D2,4,4(S)3-VCAN [Golgi lumen] (R-HSA-2065136)	0.602	3
UniProt:Q16819 MEP1A			0.558	2
UniProt:Q16820 MEP1B			0.558	2
UniProt:Q9ZFS6 Q9ZFS6			0.544	2
UniProt:P08572 COL4A2	20	3x4Hyp-3Hyp-GlcGalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2023633) 3x4Hyp-3Hyp-GalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2023568) 3x4Hyp-GalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2023589) 3x4Hyp-GlcGalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2023657) GalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2023517) GlcGalHyl-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2023630) COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-1980177) 3x4Hyp-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2022089) 3x4Hyp-3Hyp-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2022524) 3x4Hyp-5Hyl-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2022983) 3x4Hyp-3Hyp-5Hyl-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2022964) 5Hyl-COL4A2(26-1712) [endoplasmic reticulum lumen] (R-HSA-2022478) 3,4-Hyp 5-sulfiniminyl collagen alpha-2(IV) chain [extracellular region] (R-HSA-2682411) 4-Hyp 5-sulfiniminyl collagen alpha-2(IV) chain [extracellular region] (R-HSA-2682409) 5-sulfiniminyl collagen alpha-2(IV) chain [extracellular region] (R-HSA-2682392) GalHyl-COL4A2(26-?) [extracellular region] (R-HSA-2468186) 3x4Hyp-3Hyp-GalHyl-COL4A2(26-?) [extracellular region] (R-HSA-2468187) 3x4Hyp-GalHyl-COL4A2(?-1712) [extracellular region] (R-HSA-2468184) 3x4Hyp-3Hyp-5Hyl-COL4A2(26-?) [extracellular region] (R-HSA-2468185) 3x4Hyp-3Hyp-GlcGalHyl-COL4A2(26-?) [extracellular region] (R-HSA-2468190)	0.527	2
UniProt:P20908 COL5A1	20	3x4Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023553) 3x4Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023664) GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023513) GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023628) 3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023564) 3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2023647) COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022460) 3x4Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022510) 3x4Hyp-3Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022483) 3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022948) 3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022970) 5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen] (R-HSA-2022989) 3x4Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268653) COL5A1(38-1838) [extracellular region] (R-HSA-2268703) 3x4Hyp-5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268718) 3x4Hyp-GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268664) 3x4Hyp-3Hyp-COL5A1(38-1838) [extracellular region] (R-HSA-2268667) GalHyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268629) 5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268644) 3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [extracellular region] (R-HSA-2268663)	0.527	2
UniProt:P02462 COL4A1	20	GlcGalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065761) GalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065733) 3x4Hyp-3Hyp-GalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065577) 3x4Hyp-GlcGalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065690) 3x4Hyp-GalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065674) 3x4Hyp-3Hyp-GlcGalHyl-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065631) COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065778) 3x4Hyp-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065707) 3x4Hyp-3Hyp-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065624) 3x4Hyp-5Hyl-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065659) 3x4Hyp-3Hyp-5Hyl-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065589) 5Hyl-COL4A1(24-1669) [endoplasmic reticulum lumen] (R-HSA-2065736) 5-sulfiliminyl collagen alpha-1(IV) chain [extracellular region] (R-HSA-2682404) 3,4-Hyp 5-sulfiliminyl collagen alpha-1(IV) chain [extracellular region] (R-HSA-2682381) 4-Hyp 5-sulfiliminyl collagen alpha-1(IV) chain [extracellular region] (R-HSA-2682393) 3x4Hyp-COL4A1(24-?) [extracellular region] (R-HSA-2468122) COL4A1(?-1669) [extracellular region] (R-HSA-2468120) 3x4Hyp-GlcGalHyl-COL4A1(?-1669) [extracellular region] (R-HSA-2468121) COL4A1(24-?) [extracellular region] (R-HSA-2468127) 3x4Hyp-3Hyp-5Hyl-COL4A1(24-?) [extracellular region] (R-HSA-2468124)	0.527	2
UniProt:P12110 COL6A2	20	3x4Hyp-3Hyp-GalHyl-COL6A2(257-1019) [endoplasmic reticulum lumen] (R-HSA-2023552) 3x4Hyp-GalHyl-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2023555) GalHyl-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2187485) GlcGalHyl-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2187483) 3x4Hyp-GlcGalHyl-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2023675) 3x4Hyp-3Hyp-GlcGalHyl-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2023643) COL6A2 [endoplasmic reticulum lumen] (R-HSA-1614503) 3x4Hyp-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2022423) 3x4Hyp-3Hyp-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2022438) 3x4Hyp-5Hyl-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2022975) 3x4Hyp-3Hyp-5Hyl-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2022943) 5Hyl-COL6A2 [endoplasmic reticulum lumen] (R-HSA-2023007) GlcGalHyl-COL6A2(?-1019) [extracellular region] (R-HSA-2470106) 3x4Hyp-GalHyl-COL6A2(21-?) [extracellular region] (R-HSA-2470235) COL6A2(?-1019) [extracellular region] (R-HSA-2470168) 3x4Hyp-3Hyp-GalHyl-COL6A2(21-?) [extracellular region] (R-HSA-2470142) 3x4Hyp-5Hyl-COL6A2(21-?) [extracellular region] (R-HSA-2470175) 3x4Hyp-3Hyp-5Hyl-COL6A2(?-1019) [extracellular region] (R-HSA-2470076) 3x4Hyp-3Hyp-5Hyl-COL6A2(21-?) [extracellular region] (R-HSA-2470067) COL6A2(21-?) [extracellular region] (R-HSA-2470166)	0.527	2
UniProt:P12109 COL6A1	20	GalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023521) 3x4Hyp-GlcGalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023651) GlcGalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023608) 3x4Hyp-GalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023576) 3x4Hyp-3Hyp-GalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023560) 3x4Hyp-3Hyp-GlcGalHyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2023660) COL6A1 [endoplasmic reticulum lumen] (R-HSA-1614453) 3x4Hyp-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2022508) 3x4Hyp-3Hyp-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2022507) 3x4Hyp-5Hyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2022965) 3x4Hyp-3Hyp-5Hyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2022944) 5Hyl-COL6A1 [endoplasmic reticulum lumen] (R-HSA-2022997) 3x4Hyp-COL6A1(?-1028) [extracellular region] (R-HSA-2470138) COL6A1(?-1028) [extracellular region] (R-HSA-2470040) 3x4Hyp-COL6A1(20-?) [extracellular region] (R-HSA-2470073) GalHyl-COL6A1(20-?) [extracellular region] (R-HSA-2470046) 3x4Hyp-5Hyl-COL6A1(?-1028) [extracellular region] (R-HSA-2470143) 3x4Hyp-3Hyp-5Hyl-COL6A1(20-?) [extracellular region] (R-HSA-2470066) GlcGalHyl-COL6A1(20-?) [extracellular region] (R-HSA-2470033) 3x4Hyp-3Hyp-GalHyl-COL6A1(?-1028) [extracellular region] (R-HSA-2470103)	0.527	2