proMMP9 binds TIMP1

Stable Identifier
R-HSA-1602454
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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ProMMP9 binds Tissue Inhibitor of Metalloproteinases 1 (TIMP1) (Wilheim et al. 1989). By homology with the binding of TIMP2 to the MMP2 hemopexin domain, TIMP1 is thought to binds via its C domain to the MMP9 hemopexin domain. This is a two-way potential regulatory mechanism as the interaction does not prevent the free N-terminal inhibitory domain of TIMP1 from inhibiting other MMPs (Murthpy et al. 1991) while it may prevent the activation of proMMP9.

Literature References
PubMed ID Title Journal Year
2551898 SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages

Wilhelm, SM, Collier, IE, Marmer, BL, Eisen, AZ, Grant, GA, Goldberg, GI

J Biol Chem 1989
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