proMMP9 binds TIMP1

Stable Identifier
R-HSA-1602454
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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proMMP9 binds TIMP1
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ProMMP9 binds Tissue Inhibitor of Metalloproteinases 1 (TIMP1) (Wilheim et al. 1989). By homology with the binding of TIMP2 to the MMP2 hemopexin domain, TIMP1 is thought to binds via its C domain to the MMP9 hemopexin domain. This is a two-way potential regulatory mechanism as the interaction does not prevent the free N-terminal inhibitory domain of TIMP1 from inhibiting other MMPs (Murthpy et al. 1991) while it may prevent the activation of proMMP9.
Literature References
PubMed ID Title Journal Year
2551898 SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages

Eisen, AZ, Marmer, BL, Goldberg, GI, Grant, GA, Collier, IE, Wilhelm, SM

J Biol Chem 1989
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Orthologous Events
proMMP9 binds TIMP1 (Bos taurus)
proMMP9 binds TIMP1 (Caenorhabditis elegans)
proMMP9 binds TIMP1 (Canis familiaris)
proMMP9 binds TIMP1 (Danio rerio)
proMMP9 binds TIMP1 (Drosophila melanogaster)
proMMP9 binds TIMP1 (Mus musculus)
proMMP9 binds TIMP1 (Rattus norvegicus)
proMMP9 binds TIMP1 (Sus scrofa)
proMMP9 binds TIMP1 (Xenopus tropicalis)
Authored
Jupe, S  (2011-09-09)
Reviewed
Butler, GS  (2012-02-28)
Overall, CM  (2012-02-28)
Created
Jupe, S  (2011-09-14)
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