Reactome | TGFBR3_mem cleavage by MMPs

TGFBR3_mem cleavage by MMPs

Stable Identifier

R-HSA-9839367

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

3/5

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MT1‑MMP and MT3‑MMP are responsible for the ectodomain shedding of TGFBR3. Soluble fragments of TGFBR3 maintain their TGFB2/1 binding affinity and sequester these ligands from TGFBR2 receptors thus suppressing TGFb signaling. This process is inhibited by TIMP1/2 (Velasco‑Loyden et al.,2004). Studies using Metabolic Labeling and Immunoprecipitation, Affinity Labeling and Competition Experiments confirm this in L6E9, CHO and COS‑1 cell lines.

Literature References

PubMed ID	Title	Journal	Year
14672946	The shedding of betaglycan is regulated by pervanadate and mediated by membrane type matrix metalloprotease-1 Arribas, J, Velasco-Loyden, G, López-Casillas, F	J Biol Chem	2004
8106553	Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites Payne, HM, López-Casillas, F, Massagué, J, Andres, JL	J Cell Biol	1994