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Bradykinin [extracellular region]
Stable Identifier
R-HSA-158344
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
KNG1(381-389)
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Intrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Bradykinin receptors B1 and B2 bind to bradykinin (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01042 KNG1
Gene Names
KNG1, BDK, KNG
Chain
signal peptide:1-18, chain:19-644, chain:19-380, peptide:376-389, peptide:380-389, peptide:381-389, chain:390-644, peptide:431-434
Reference Genes
BioGPS Gene:3827 KNG1
COSMIC (genes):KNG1 KNG1
CTD Gene:3827 KNG1
dbSNP Gene:3827 KNG1
ENSEMBL:ENSG00000113889 KNG1
HGNC:6383 KNG1
KEGG Gene (Homo sapiens):3827 KNG1
Monarch:3827 KNG1
NCBI Gene:3827 KNG1
OMIM:612358 KNG1
UCSC:P01042 KNG1
Reference Transcript
RefSeq:NM_001102416.2 KNG1
RefSeq:NM_000893.3 KNG1
RefSeq:NM_001166451.1 KNG1
Other Identifiers
0002480086
11729956_a_at
11729957_x_at
11739129_at
11750241_x_at
16949348
206054_at
217512_at
243562_at
2656690
2656691
2656692
2656693
2656694
2656697
2656699
2656700
2656701
2656702
2656703
2656704
2656705
2656707
2656708
2656709
2656710
2656711
2656712
2656713
2656714
2656731
37234_at
37235_g_at
37236_at
3827
56482_at
8084679
89933_at
A_23_P212258
A_24_P60381
A_32_P230808
GE517374
GE60500
GO:0002576
GO:0003013
GO:0003674
GO:0004866
GO:0004869
GO:0005102
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005783
GO:0005788
GO:0005886
GO:0006464
GO:0006810
GO:0006950
GO:0006954
GO:0007155
GO:0007162
GO:0007165
GO:0007186
GO:0007204
GO:0007596
GO:0007597
GO:0007599
GO:0008150
GO:0008201
GO:0008219
GO:0008270
GO:0010466
GO:0010951
GO:0016192
GO:0030195
GO:0030234
GO:0030414
GO:0031012
GO:0031093
GO:0031410
GO:0042311
GO:0042592
GO:0043065
GO:0043167
GO:0043226
GO:0043687
GO:0044267
GO:0045861
GO:0062023
GO:0070062
GO:0072562
HMNXSV003004823
HMNXSV003008016
Hs.117112.0.A1_3p_at
Hs.289056.0.S1_3p_at
ILMN_1753729
M11437_cds1_at
M11437_cds2_at
PH_hs_0004485
TC03001024.hg
g4504892_3p_at
Participates
as an output of
kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Homo sapiens)
as an input of
Bradykinin receptors B1 and B2 bind to bradykinin (Homo sapiens)
as a member of
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
as a component of
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Other forms of this molecule
KNG1(19-644) [platelet alpha granule lumen]
p-KNG1 [endoplasmic reticulum lumen]
KNG1 [endoplasmic reticulum lumen]
KNG1(19-644) [plasma membrane]
KNG1(390-644) [plasma membrane]
KNG1(19-380) [plasma membrane]
KNG1(19-644) [extracellular region]
Inferred To
Ghost homologue of Bradykinin [extracellular region]
(Rattus norvegicus)
KNG1 [extracellular region]
(Bos taurus)
KNG1 [extracellular region]
(Canis familiaris)
KNG1 [extracellular region]
(Gallus gallus)
KNG1 [extracellular region]
(Sus scrofa)
kng1 [extracellular region]
(Danio rerio)
Kng2 [extracellular region]
(Mus musculus)
Cross References
RefSeq
NP_000884.1
,
NP_001159923.1
,
NP_001095886.1
OpenTargets
ENSG00000113889
GeneCards
P01042
HPA
ENSG00000113889-KNG1
Ensembl
ENST00000287611
,
ENSP00000493985
,
ENSP00000396025
,
ENSG00000113889
,
ENSP00000287611
,
ENST00000644859
,
ENST00000447445
PRO
P01042
Orphanet
16311
HMDB Protein
HMDBP02063
PDB
2WOK
,
4ASR
,
6F3Y
,
5I25
,
6F3W
,
1NY2
,
4ECC
,
6F27
,
4ASQ
,
6F3X
,
4ECB
,
6F3V
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q10714
3
Ance [extracellular region]
(R-DME-2065414-2)
Ance [plasma membrane]
(R-DME-2022344-2)
Ance [plasma membrane]
(R-DME-508496-2)
0.558
2
UniProt:Q07021 C1QBP
3
C1QBP [mitochondrial matrix]
(R-HSA-9645697)
C1QBP [plasma membrane]
(R-HSA-158123)
C1QBP [cytosol]
(R-HSA-9645690)
0.544
4
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