Reactome | Bradykinin [extracellular region]

Bradykinin [extracellular region]

Stable Identifier

R-HSA-158344

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

KNG1(381-389)

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P01042 KNG1

Gene Names

KNG1, BDK, KNG

Chain

signal peptide:1-18, chain:19-644, chain:19-380, peptide:376-389, peptide:380-389, peptide:381-389, chain:390-644, peptide:431-434

Reference Genes

BioGPS Gene:3827 KNG1

COSMIC (genes):KNG1 KNG1

CTD Gene:3827 KNG1

dbSNP Gene:3827 KNG1

ENSEMBL:ENSG00000113889 KNG1

HGNC:6383 KNG1

KEGG Gene (Homo sapiens):3827 KNG1

Monarch:3827 KNG1

NCBI Gene:3827 KNG1

OMIM:612358 KNG1

UCSC:P01042 KNG1

Reference Transcript

Other Identifiers

0002480086

11729956_a_at

11729957_x_at

11739129_at

11750241_x_at

16949348

206054_at

217512_at

243562_at

2656690

2656691

2656692

2656693

2656694

2656697

2656699

2656700

2656701

2656702

2656703

2656704

2656705

2656707

2656708

2656709

2656710

2656711

2656712

2656713

2656714

2656731

37234_at

37235_g_at

37236_at

3827

56482_at

8084679

89933_at

A_23_P212258

A_24_P60381

A_32_P230808

GE517374

GE60500

GO:0002576

GO:0003013

GO:0003674

GO:0004866

GO:0004869

GO:0005102

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0005886

GO:0006464

GO:0006810

GO:0006950

GO:0006954

GO:0007155

GO:0007162

GO:0007165

GO:0007186

GO:0007204

GO:0007596

GO:0007597

GO:0007599

GO:0008150

GO:0008201

GO:0008219

GO:0008270

GO:0010466

GO:0010951

GO:0016192

GO:0030195

GO:0030234

GO:0030414

GO:0031012

GO:0031093

GO:0031410

GO:0042311

GO:0042592

GO:0043065

GO:0043167

GO:0043226

GO:0043687

GO:0044267

GO:0045861

GO:0062023

GO:0070062

GO:0072562

HMNXSV003004823

HMNXSV003008016

Hs.117112.0.A1_3p_at

Hs.289056.0.S1_3p_at

ILMN_1753729

M11437_cds1_at

M11437_cds2_at

PH_hs_0004485

TC03001024.hg

g4504892_3p_at

Participates

as an output of

kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Homo sapiens)

as an input of

Bradykinin receptors B1 and B2 bind to bradykinin (Homo sapiens)

as a member of

Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)

as a component of

Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)

Other forms of this molecule

KNG1(19-644) [platelet alpha granule lumen]

p-KNG1 [endoplasmic reticulum lumen]

KNG1 [endoplasmic reticulum lumen]

KNG1(19-644) [plasma membrane]

KNG1(390-644) [plasma membrane]

KNG1(19-380) [plasma membrane]

KNG1(19-644) [extracellular region]

Inferred To

Ghost homologue of Bradykinin [extracellular region] (Rattus norvegicus)

KNG1 [extracellular region] (Bos taurus)

KNG1 [extracellular region] (Canis familiaris)

KNG1 [extracellular region] (Gallus gallus)

KNG1 [extracellular region] (Sus scrofa)

kng1 [extracellular region] (Danio rerio)

Kng2 [extracellular region] (Mus musculus)

Cross References

RefSeq

NP_000884.1, NP_001159923.1, NP_001095886.1

OpenTargets

ENSG00000113889

GeneCards

P01042

HPA

ENSG00000113889-KNG1

Ensembl

ENST00000287611, ENSP00000493985, ENSP00000396025, ENSG00000113889, ENSP00000287611, ENST00000644859, ENST00000447445

PRO

P01042

Orphanet

16311

HMDB Protein

HMDBP02063

PDB

2WOK, 4ASR, 6F3Y, 5I25, 6F3W, 1NY2, 4ECC, 6F27, 4ASQ, 6F3X, 4ECB, 6F3V

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q10714	3	Ance [extracellular region] (R-DME-2065414-2) Ance [plasma membrane] (R-DME-2022344-2) Ance [plasma membrane] (R-DME-508496-2)	0.558	2
UniProt:Q07021 C1QBP	3	C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123) C1QBP [cytosol] (R-HSA-9645690)	0.544	4

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