Reactome | Bradykinin [extracellular region]

Bradykinin [extracellular region]

Stable Identifier

R-HSA-158344

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

KNG1(381-389)

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P01042 KNG1

Gene Names

KNG1, BDK, KNG

Chain

signal peptide:1-18, chain:19-644, chain:19-380, peptide:376-389, peptide:380-389, peptide:381-389, chain:390-644, peptide:431-434

Reference Genes

BioGPS Gene:3827 KNG1

COSMIC - genes:KNG1 KNG1

CTD Gene:3827 KNG1

dbSNP Gene:3827 KNG1

ENSEMBL:ENSG00000113889 KNG1

HGNC:6383 KNG1

KEGG:hsa:3827 KNG1

Monarch:3827 KNG1

NCBI Gene:3827 KNG1

OMIM:612358 KNG1

UCSC:P01042 KNG1

Reference Transcript

Participates

as an output of

kallikrein:kininogen:cell surface receptor -> kallikrein + cleaved kininogen:cell surface receptor + bradykinin (Homo sapiens)

as a member of

Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)

as an input of

Bradykinin receptors B1 and B2 bind to bradykinin (Homo sapiens)

as a component of

Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)

Other forms of this molecule

KNG1(19-644) [platelet alpha granule lumen]

KNG1(19-644) [extracellular region]

KNG1(19-644) [plasma membrane]

KNG1 [endoplasmic reticulum lumen]

p-KNG1 [endoplasmic reticulum lumen]

KNG1(390-644) [plasma membrane]

KNG1(19-380) [plasma membrane]

Inferred To

KNG1 [extracellular region] (Bos taurus)

KNG1 [extracellular region] (Canis familiaris)

KNG1 [extracellular region] (Gallus gallus)

KNG1 [extracellular region] (Sus scrofa)

kng1 [extracellular region] (Xenopus tropicalis)

Kng1 [extracellular region] (Rattus norvegicus)

Kng2 [extracellular region] (Mus musculus)

Cross References

RefSeq

NP_000884.1, NP_001095886.1, NP_001159923.1

OpenTargets

ENSG00000113889

ENSEMBL

ENSP00000396025, ENSP00000493985, ENST00000287611, ENSG00000113889, ENST00000644859, ENSP00000287611, ENST00000447445

HPA

ENSG00000113889-KNG1

GeneCards

KNG1

PRO

P01042

Pharos - Targets

P01042

Orphanet

KNG1

GlyGen

P01042

HMDB Protein

HMDBP02063

PDB

1NY2, 7EIB, 8VJX, 4ASR, 6F27, 6F3V, 7F2O, 4ECC, 7QOX, 4ASQ, 2WOK, 7F6H, 4ECB, 7F6I, 5I25, 6F3Y, 7QOT, 6F3W, 6F3X

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q10714	2	ACE(30-1232) [extracellular region] (R-DME-2065414-2) ACE(30-1306) [plasma membrane] (R-DME-508496-2)	0.558	2
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.544	4
UniProt:O60911 CTSV	4	CTSL2 [endolysosome lumen] (R-HSA-4127477) CTSL2 [early endosome lumen] (R-HSA-4127471) CTSL2 [extracellular region] (R-HSA-2228669) CTSL2 [lysosomal lumen] (R-HSA-1181232)	0.527	2
UniProt:Q9H1A4 ANAPC1	2	ANAPC1 [cytosol] (R-HSA-174189) ANAPC1 [nucleoplasm] (R-HSA-174217)	0.527	2
UniProt:P07384 CAPN1	4	CAPN1 [ficolin-1-rich granule lumen] (R-HSA-6801284) CAPN1 [extracellular region] (R-HSA-6806485) CAPN1 [cytosol] (R-HSA-3288367) CAPN1 [plasma membrane] (R-HSA-3828038)	0.527	2