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Bradykinin [extracellular region]
Stable Identifier
R-HSA-158344
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
KNG1(381-389)
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Intrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Bradykinin receptors B1 and B2 bind to bradykinin (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Bradykinin [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01042 KNG1
Gene Names
KNG1, BDK, KNG
Chain
signal peptide:1-18, chain:19-644, chain:19-380, peptide:376-389, peptide:380-389, peptide:381-389, chain:390-644, peptide:431-434
Reference Genes
COSMIC (genes):KNG1 KNG1
dbSNP Gene:3827 KNG1
ENSEMBL:ENSG00000113889 KNG1
Participates
as an output of
kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin (Homo sapiens)
as a member of
Ligands of GPCRs that activate Gq/11 [extracellular region] (Homo sapiens)
as an input of
Bradykinin receptors B1 and B2 bind to bradykinin (Homo sapiens)
as a component of
Bradykinin receptor:Bradykinin [plasma membrane] (Homo sapiens)
Other forms of this molecule
KNG1(19-644) [platelet alpha granule lumen]
KNG1(19-380) [plasma membrane]
KNG1(390-644) [plasma membrane]
KNG1(19-644) [plasma membrane]
KNG1(19-644) [extracellular region]
p-KNG1 [endoplasmic reticulum lumen]
KNG1 [endoplasmic reticulum lumen]
Inferred To
KNG1 [extracellular region]
(Bos taurus)
KNG1 [extracellular region]
(Canis familiaris)
KNG1 [extracellular region]
(Sus scrofa)
kng1 [extracellular region]
(Xenopus tropicalis)
Bradykinin [extracellular region]
(Gallus gallus)
Kng1 [extracellular region]
(Rattus norvegicus)
Kng2 [extracellular region]
(Mus musculus)
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q10714
2
ACE(30-1232) [extracellular region]
(R-DME-2065414-2)
ACE(30-1306) [plasma membrane]
(R-DME-508496-2)
0.558
2
UniProt:Q07021 C1QBP
3
C1QBP [plasma membrane]
(R-HSA-158123)
C1QBP [mitochondrial matrix]
(R-HSA-9645697)
C1QBP [cytosol]
(R-HSA-9645690)
0.544
4
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