Reactome | KNG1(390-644) [plasma membrane]

KNG1(390-644) [plasma membrane]

Stable Identifier

R-HSA-158279

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

kininogen light chain, high molecular weight kininogen light chain

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P01042 KNG1

Gene Names

KNG1, BDK, KNG

Chain

signal peptide:1-18, chain:19-644, chain:19-380, peptide:376-389, peptide:380-389, peptide:381-389, chain:390-644, peptide:431-434

Reference Genes

BioGPS Gene:3827 KNG1

COSMIC (genes):KNG1 KNG1

CTD Gene:3827 KNG1

dbSNP Gene:3827 KNG1

ENSEMBL:ENSG00000113889 KNG1

HGNC:6383 KNG1

KEGG:hsa:3827 KNG1

Monarch:3827 KNG1

NCBI Gene:3827 KNG1

OMIM:612358 KNG1

UCSC:P01042 KNG1

Reference Transcript

Participates

as a component of

activated kininogen [plasma membrane] (Homo sapiens)

Other forms of this molecule

Bradykinin [extracellular region]

KNG1 [endoplasmic reticulum lumen]

p-KNG1 [endoplasmic reticulum lumen]

KNG1(19-644) [platelet alpha granule lumen]

KNG1(19-644) [extracellular region]

KNG1(19-644) [plasma membrane]

KNG1(19-380) [plasma membrane]

Inferred To

KNG1 [plasma membrane] (Bos taurus)

KNG1 [plasma membrane] (Canis familiaris)

KNG1 [plasma membrane] (Sus scrofa)

kng1 [plasma membrane] (Xenopus tropicalis)

Kng1 [plasma membrane] (Rattus norvegicus)

KNG1(390-644) [plasma membrane] (Gallus gallus)

Kng2 [plasma membrane] (Mus musculus)

Cross References

RefSeq

NP_000884.1, NP_001095886.1, NP_001159923.1

OpenTargets

ENSG00000113889

ENSEMBL

ENSP00000287611, ENST00000287611, ENSP00000396025, ENSG00000113889, ENST00000644859, ENSP00000493985, ENST00000447445

HPA

ENSG00000113889-KNG1

GeneCards

KNG1

PRO

P01042

Pharos - Targets

P01042

Orphanet

KNG1

GlyGen

P01042

HMDB Protein

HMDBP02063

PDB

4ASR, 7F6I, 4ASQ, 1NY2, 4ECC, 7F6H, 4ECB, 7QOX, 2WOK, 6F3V, 7F2O, 7EIB, 6F27, 8VJX, 6F3W, 6F3X, 5I25, 7QOT, 6F3Y

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q10714	2	Ance [extracellular region] (R-DME-2065414-2) Ance [plasma membrane] (R-DME-508496-2)	0.558	2
UniProt:Q07021 C1QBP	3	C1QBP [cytosol] (R-HSA-9645690) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [plasma membrane] (R-HSA-158123)	0.544	4
UniProt:O60911 CTSV	4	CTSL2 [endolysosome lumen] (R-HSA-4127477) CTSL2 [extracellular region] (R-HSA-2228669) CTSL2 [early endosome lumen] (R-HSA-4127471) CTSL2 [lysosomal lumen] (R-HSA-1181232)	0.527	2
UniProt:Q9H1A4 ANAPC1	2	ANAPC1 [cytosol] (R-HSA-174189) ANAPC1 [nucleoplasm] (R-HSA-174217)	0.527	2
UniProt:P07384 CAPN1	4	CAPN1 [ficolin-1-rich granule lumen] (R-HSA-6801284) CAPN1 [extracellular region] (R-HSA-6806485) CAPN1 [cytosol] (R-HSA-3288367) CAPN1 [plasma membrane] (R-HSA-3828038)	0.527	2

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