Reactome | CAST [cytosol]

CAST [cytosol]

Stable Identifier

R-HSA-8848644

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Calpastatin, ICAL_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P20810 CAST

Gene Names

CAST

Chain

chain:1-708

Reference Genes

BioGPS Gene:831 CAST

COSMIC (genes):CAST CAST

CTD Gene:831 CAST

dbSNP Gene:831 CAST

ENSEMBL:ENSG00000153113 CAST

ENSEMBL_homo_sapiens_GENE:ENSG00000153113.24 CAST

HGNC:1515 CAST

KEGG Gene (Homo sapiens):831 CAST

Monarch:831 CAST

NCBI Gene:831 CAST

OMIM:114090 CAST

UCSC:P20810 CAST

Reference Transcript

Other Identifiers

11722584_a_at

11722585_a_at

11737143_a_at

11744916_x_at

11750050_a_at

11750051_x_at

11755834_x_at

11756711_x_at

11757397_s_at

16987468

207467_PM_x_at

207467_x_at

208908_PM_s_at

208908_s_at

212580_PM_at

212580_at

212586_PM_at

212586_at

2821203

2821204

2821205

2821206

2821211

2821218

2821219

2821223

2821225

2821226

2821227

2821234

2821235

2821236

2821239

2821240

2821241

2821244

2821245

2821248

2821249

2821250

2821251

2821255

2821263

2821264

2821266

2821268

2821273

2821274

2821278

2821279

2821281

2821283

2821285

2821287

2821288

2821290

2821293

2821294

2821295

2821296

2821297

2821298

2821299

2821300

2821301

2821302

2821303

2821304

33385_g_at

41257_at

58440_s_at

8107005

831

A_14_P123991

A_14_P126729

A_14_P139850

A_23_P213518

A_23_P434352

D16217_at

GE81065

GO:0003723

GO:0004866

GO:0004869

GO:0005515

GO:0005737

GO:0005783

GO:0005829

GO:0010859

GO:0012501

GO:0016020

GO:0030414

GO:0034330

GO:0043226

GO:0045296

GO:0051604

GO:0097340

GO:0098772

GO:1990709

GO:2000675

HMNXSV003004720

HMNXSV003022966

Hs.247043.2.A1_3p_at

Hs.247043.2.A2_3p_at

ILMN_1672947

ILMN_1717234

ILMN_1783627

ILMN_2322806

PH_hs_0025820

TC05002526.hg

TC05002527.hg

g12056961_3p_a_at

Participates

as a component of

Calpain1,Calpain2:Ca2+:CAST [plasma membrane] (Homo sapiens)

as an input of

CAST binds Ca2+ bound calpain (Homo sapiens)

This entity regulates

Negatively

CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins (Homo sapiens)

Inferred To

Cast [cytosol] (Mus musculus)

Cast [cytosol] (Rattus norvegicus)

Homologues of CAST [cytosol] (Sus scrofa)

CAST [cytosol] (Bos taurus)

CAST [cytosol] (Canis familiaris)

CAST [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001035905.1, NP_001741.4, NP_001035907.1, NP_001035906.1, XP_016865402.1, XP_006714766.1, XP_006714767.1, XP_006714759.1, XP_006714764.1, NP_001271141.1, NP_001035909.1, NP_001317560.1, NP_001035908.1, NP_775083.1

OpenTargets

ENSG00000153113

GeneCards

P20810

HPA

ENSG00000153113-CAST

Ensembl

ENST00000674984, ENSP00000312523, ENSP00000339914, ENSP00000501872, ENSP00000343421, ENST00000675179, ENST00000675033, ENST00000395812, ENST00000309190, ENSP00000425721, ENST00000395813, ENSP00000501659, ENSG00000153113, ENST00000341926, ENSP00000422176, ENST00000338252, ENST00000510756, ENST00000508830, ENSP00000379158, ENSP00000379157, ENSP00000501713

PRO

P20810

Pharos - Targets

P20810

Orphanet

23596

HMDB Protein

HMDBP07738

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P17655 CAPN2	2	CAPN2 [cytosol] (R-HSA-8848630) CAPN2 [plasma membrane] (R-HSA-8863405)	0.688	3
UniProt:P07384 CAPN1	4	CAPN1 [plasma membrane] (R-HSA-3828038) CAPN1 [cytosol] (R-HSA-3288367) CAPN1 [extracellular region] (R-HSA-6806485) CAPN1 [ficolin-1-rich granule lumen] (R-HSA-6801284)	0.527	3