Farnesyltransferase/geranyl-geranyltransferase catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. This enzyme complex consists of a heterodimer of an alpha and a beta subunit. The alpha subunit is thought to function in the formation of a stable complex with the substrate. This alpha subnit is cleaved by caspase 3. Expression of the cleavage product (60-379) induces cell death (Kim et al., 2001).
Kim, KW, Chung, HH, Chung, CW, Kim, IK, Miura, M, Wang, S, Zhu, H, Moon, KD, Rha, GB, Park, JH, Jo, DG, Woo, HN, Song, YH, Kim, BJ, Yuan, J, Jung, YK
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