Reactome | Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha

Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha

Stable Identifier

R-HSA-201640

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha

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Farnesyltransferase/geranyl-geranyltransferase catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. This enzyme complex consists of a heterodimer of an alpha and a beta subunit. The alpha subunit is thought to function in the formation of a stable complex with the substrate. This alpha subnit is cleaved by caspase 3. Expression of the cleavage product (60-379) induces cell death (Kim et al., 2001).

Literature References

PubMed ID	Title	Journal	Year
11313965	Inactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3: cleavage of the common alpha subunit during apoptosis Kim, KW, Chung, HH, Chung, CW, Kim, IK, Miura, M, Wang, S, Zhu, H, Moon, KD, Rha, GB, Park, JH, Jo, DG, Woo, HN, Song, YH, Kim, BJ, Yuan, J, Jung, YK	Oncogene	2001