Reactome | CCP110 [cytosol]

CCP110 [cytosol]

Stable Identifier

R-HSA-380261

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cep110

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP33 deubiquitinates CCP110,ARRB (Homo sapiens)
        
        USP33:CCP110,ARRB1,ARRB2 [cytosol] (Homo sapiens)
        
        CCP110,ARRB2,(ARRB1) [cytosol] (Homo sapiens)
        
        CCP110 [cytosol] (Homo sapiens)

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CCP110 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CCP110 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        CCP110 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CCP110 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - CCP110 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CCP110 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CCP110 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CCP110 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CCP110 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CCP110 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O43303 CCP110

Gene Names

CCP110, CEP110, CP110, KIAA0419

Chain

chain:1-1012

Reference Genes

BioGPS Gene:9738 CCP110

COSMIC (genes):CCP110 CCP110

CTD Gene:9738 CCP110

dbSNP Gene:9738 CCP110

ENSEMBL:ENSG00000103540 CCP110

HGNC:24342 CCP110

KEGG:hsa:9738 CCP110

Monarch:9738 CCP110

NCBI Gene:9738 CCP110

OMIM:609544 CCP110

UCSC:O43303 CCP110

Reference Transcript

Other Identifiers

11728368_s_at

11728369_x_at

11745800_a_at

1569353_PM_at

1569353_at

16816479

204662_PM_at

204662_at

3651019

3651020

3651021

3651022

3651023

3651024

3651025

3651026

3651027

3651028

3651029

3651030

3651031

3651034

3651037

3651039

3651042

3651043

3651044

3651045

3651046

3651047

3651048

3651052

3651053

3651054

3651055

3651056

3651058

37438_at

7993664

9738

A_14_P126947

A_14_P128349

A_23_P26501

A_24_P373286

GE62355

GO:0005515

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0005929

GO:0007099

GO:0030030

GO:0032053

GO:0032465

GO:0032991

GO:0043226

GO:0044782

GO:0045724

GO:0051298

GO:1902018

GO:1903723

HMNXSV003018448

Hs2.399808.1.S1_3p_at

ILMN_1773200

PH_hs_0014428

TC16000215.hg

g7662105_3p_at

Participates

as a candidate of

RHOV effectors [cytosol] (Homo sapiens)

as an output of

CP110 and CEP97 dissociate from the centriole (Homo sapiens)

as a component of

as a member of

CCP110,ARRB2,(ARRB1) [cytosol] (Homo sapiens)

Other forms of this molecule

PolyUb-CCP110 [cytosol]

Inferred To

CCP110 [cytosol] (Bos taurus)

CCP110 [cytosol] (Canis familiaris)

CCP110 [cytosol] (Gallus gallus)

CCP110 [cytosol] (Sus scrofa)

ccp110 [cytosol] (Xenopus tropicalis)

Ccp110 [cytosol] (Mus musculus)

Ccp110 [cytosol] (Rattus norvegicus)

Cp110 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001185951.2, NP_001310498.1, NP_001310499.1, XP_011544294.1, XP_011544293.1, NP_001310500.1, NP_001310501.1, XP_016879397.1, NP_055526.4

OpenTargets

ENSG00000103540

ENSEMBL

ENST00000396212, ENST00000381396, ENSP00000370803, ENSP00000379511, ENST00000396208, ENST00000694978, ENSP00000511625, ENSP00000379515

HPA

ENSG00000103540-CCP110

PRO

O43303

Pharos - Targets

O43303

GlyGen

O43303

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IW35 CEP97	1	CEP97 [cytosol] (R-HSA-5626440)	0.953	31
UniProt:P62158 CALM			0.905	15
UniProt:O15078 CEP290	3	CEP290 [extracellular region] (R-HSA-6806291) CEP290 [specific granule lumen] (R-HSA-6799524) CEP290 [cytosol] (R-HSA-380275)	0.888	18
UniProt:Q5T7B8 KIF24	1	KIF24 [cytosol] (R-HSA-5626651)	0.81	15
UniProt:P41002 CCNF	1	CCNF [cytosol] (R-HSA-8862602)	0.788	9
UniProt:Q8TAP6 CEP76	1	CEP76 [cytosol] (R-HSA-380281)	0.706	7
UniProt:Q96JN8 NEUL4			0.644	9
UniProt:P41208 CETN2	3	CETN2 [cytosol] (R-HSA-380298) CETN2 [nucleoplasm] (R-HSA-4570490) polySUMO2,3-CETN2 [nucleoplasm] (R-HSA-4570486)	0.641	5
UniProt:Q8NHV4 NEDD1	1	NEDD1 [cytosol] (R-HSA-379267)	0.619	3
UniProt:Q15154 PCM1	1	PCM1 [cytosol] (R-HSA-380308)	0.615	4
UniProt:Q9BVV6 TALD3			0.558	6
UniProt:Q9UKX7 NUP50	1	NUP50 [nucleoplasm] (R-HSA-157740)	0.499	4
UniProt:Q9Y6M1 IGF2BP2	1	IGF2BP2 [cytosol] (R-HSA-428302)	0.483	3
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.483	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.483	3

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