NEDD4L binds phosphorylated linker region of SMAD2/3

Stable Identifier
R-HSA-2176491
Type
Reaction
Species
Homo sapiens
Compartment
nucleoplasm
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NEDD4L binds phosphorylated linker region of SMAD2/3
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Phosphorylation of the linker region of SMAD2 and SMAD3 by CDK8 or CDK9 creates a docking site for E3-ubiquitin ligase NEDD4L.

Literature References
PubMed ID Title Journal Year
19917253 Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling

Massague, J, Chen, PY, Macias, MJ, Tempst, P, Goerner, N, Gao, S, Sapkota, G, Alarcon, C, Erdjument-Bromage, H, Rahman, S

Mol Cell 2009
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Orthologous Events
NEDD4L binds phosphorylated linker region of SMAD2/3 (Caenorhabditis elegans)
NEDD4L binds phosphorylated linker region of SMAD2/3 (Canis familiaris)
NEDD4L binds phosphorylated linker region of SMAD2/3 (Danio rerio)
NEDD4L binds phosphorylated linker region of SMAD2/3 (Drosophila melanogaster)
NEDD4L binds phosphorylated linker region of SMAD2/3 (Mus musculus)
NEDD4L binds phosphorylated linker region of SMAD2/3 (Rattus norvegicus)
NEDD4L binds phosphorylated linker region of SMAD2/3 (Sus scrofa)
NEDD4L binds phosphorylated linker region of SMAD2/3 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2012-04-04)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-04-02)
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