NEDD4L ubiquitinates SMAD2/3

Stable Identifier
R-HSA-2176502
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NEDD4L ubiquitinates SMAD2/3
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NEDD4L ubiquitinates nuclear SMAD2 and SMAD3 phosphorylated at the linker region by CDK8 or CDK9, targeting SMAD2 and SMAD3 for degradation.

Literature References
PubMed ID Title Journal Year
19917253 Ubiquitin ligase Nedd4L targets activated Smad2/3 to limit TGF-beta signaling

Massague, J, Chen, PY, Macias, MJ, Tempst, P, Goerner, N, Gao, S, Sapkota, G, Alarcon, C, Erdjument-Bromage, H, Rahman, S

Mol Cell 2009
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Orthologous Events
NEDD4L ubiquitinates SMAD2/3 (Bos taurus)
NEDD4L ubiquitinates SMAD2/3 (Caenorhabditis elegans)
NEDD4L ubiquitinates SMAD2/3 (Canis familiaris)
NEDD4L ubiquitinates SMAD2/3 (Danio rerio)
NEDD4L ubiquitinates SMAD2/3 (Drosophila melanogaster)
NEDD4L ubiquitinates SMAD2/3 (Gallus gallus)
NEDD4L ubiquitinates SMAD2/3 (Mus musculus)
NEDD4L ubiquitinates SMAD2/3 (Rattus norvegicus)
NEDD4L ubiquitinates SMAD2/3 (Sus scrofa)
NEDD4L ubiquitinates SMAD2/3 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Contreras, O  (2022-05-02)
Created
Orlic-Milacic, M  (2012-04-03)
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