Reactome | NEDD4L ubiquitin ligase binds SMAD7

NEDD4L ubiquitin ligase binds SMAD7

Stable Identifier

R-HSA-2176416

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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NEDD4L ubiquitin ligase, structurally similar to SMURF ubiquitin ligases, binds SMAD7 (Kuratomi et al. 2005). This was inferred from experiments that used recombinant mouse Smad7 and recombinant human NEDD4L.

Literature References

PubMed ID	Title	Journal	Year
15496141	NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor Kuratomi, G, Komuro, A, Goto, K, Shinozaki, M, Miyazawa, K, Miyazono, K, Imamura, T	Biochem J	2005

Participants

Input

Output

SMAD7:NEDD4L [nucleoplasm] (Homo sapiens)

Participant Of

hasEvent

Downregulation of TGF-beta receptor signaling

Inferred From

NEDD4L binds Smad7 (Homo sapiens)

Authored

Orlic-Milacic, M (2012-04-05)

Reviewed

Huang, T (2012-05-14)

Created

Orlic-Milacic, M (2012-04-02)