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NEDD4L ubiquitin ligase binds SMAD7
Stable Identifier
R-HSA-2176416
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
NEDD4L ubiquitin ligase binds SMAD7 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
NEDD4L ubiquitin ligase, structurally similar to SMURF ubiquitin ligases, binds SMAD7 (Kuratomi et al. 2005). This was inferred from experiments that used recombinant mouse Smad7 and recombinant human NEDD4L.
Literature References
PubMed ID
Title
Journal
Year
15496141
NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor
Miyazono, K
,
Goto, K
,
Kuratomi, G
,
Shinozaki, M
,
Imamura, T
,
Komuro, A
,
Miyazawa, K
Biochem J
2005
Participants
Input
NEDD4L [nucleoplasm]
(Homo sapiens)
SMAD7 [nucleoplasm]
(Homo sapiens)
Output
SMAD7:NEDD4L [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Downregulation of TGF-beta receptor signaling (Homo sapiens)
Inferred From
NEDD4L binds Smad7 (Homo sapiens)
Authored
Orlic-Milacic, M (2012-04-05)
Reviewed
Huang, T (2012-05-14)
Created
Orlic-Milacic, M (2012-04-02)
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