PRKCQ(355-706) [cytosol]

Stable Identifier
R-HSA-212514
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein kinase C, theta type fragment (355-706), nPKC-theta
Icon
PRKCQ(355-706) [cytosol] icon
PRKCQ(355-706) [cytosol] icon
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
9431985 The proteolytic cleavage of protein kinase C isotypes, which generates kinase and regulatory fragments, correlates with Fas-mediated and 12-O-tetradecanoyl-phorbol-13-acetate-induced apoptosis

Kobayashi, Y, Ohno, S, Shimonaka, M, Araki, T, Akita, Y, Noda, K, Kishi, S, Imaoka, T, Mizuno, K

Eur J Biochem 1997
9252332 Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis

Yoshida, K, Kojima, H, Kufe, D, Datta, R

J Biol Chem 1997
External Reference Information
External Reference
UniProt:Q04759 PRKCQ
Gene Names
PRKCQ, PRKCT
Chain
chain:1-706
Reference Genes
BioGPS Gene:5588 PRKCQ
COSMIC (genes):PRKCQ PRKCQ
CTD Gene:5588 PRKCQ
dbSNP Gene:5588 PRKCQ
ENSEMBL:ENSG00000065675 PRKCQ
HGNC:9410 PRKCQ
KEGG Gene (Homo sapiens):5588 PRKCQ
Monarch:5588 PRKCQ
NCBI Gene:5588 PRKCQ
OMIM:600448 PRKCQ
UCSC:Q04759 PRKCQ
Reference Transcript
Other Identifiers
0002940053
11728077_s_at
11747467_a_at
11750753_a_at
16711533
2081_s_at
210038_PM_at
210038_at
210039_PM_s_at
210039_s_at
3275955
3275956
3275957
3275958
3275959
3275960
3275963
3275967
3275969
3275971
3275972
3275977
3275978
3275979
3275981
3275987
3275989
3275990
3275991
3275995
3275997
3276002
3276010
3276011
38949_at
5588
7931930
A_23_P1374
GE79759
GE88182
GO:0000166
GO:0000902
GO:0001558
GO:0001772
GO:0002376
GO:0003674
GO:0004672
GO:0004674
GO:0004697
GO:0004698
GO:0004712
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005737
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0006259
GO:0006355
GO:0006464
GO:0006468
GO:0006509
GO:0006950
GO:0006954
GO:0007155
GO:0007165
GO:0007411
GO:0008150
GO:0008219
GO:0008283
GO:0009058
GO:0016020
GO:0016235
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0030154
GO:0032212
GO:0032740
GO:0032743
GO:0032753
GO:0034451
GO:0034641
GO:0035556
GO:0038095
GO:0040007
GO:0040011
GO:0042102
GO:0043167
GO:0043226
GO:0046627
GO:0046872
GO:0048856
GO:0048870
GO:0050870
GO:0051092
GO:0051276
GO:0051973
GO:0060326
GO:0070233
GO:0090330
GO:0106310
GO:1904355
GO:2000318
GO:2000570
HMNXSV003003840
HMNXSV003036575
Hs.211593.0.S2_3p_at
ILMN_1733421
L01087_at
PH_hs_0024719
PH_hs_0033184
TC10001014.hg
g558098_3p_a_at
Participates
as an output of
Other forms of this molecule
PRKCQ [photoreceptor disc membrane]
p-Y90,T538,S676,S695-PRKCQ [plasma membrane]
PRKQC closed conformation [cytosol]
PRKCQ [plasma membrane]
p-Y90-PRKCQ [plasma membrane]
p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane]
PRKCQ(1-354) [cytosol]
PRKCQ [cytosol]
Inferred To
PKC1 [cytosol] (Saccharomyces cerevisiae)
pck1 [cytosol] (Schizosaccharomyces pombe)
tpa-1 [cytosol] (Caenorhabditis elegans)
PRKCQ [cytosol] (Bos taurus)
PRKCQ [cytosol] (Canis familiaris)
PRKCQ [cytosol] (Sus scrofa)
Homologues of PRKCQ(355-706) [cytosol] (Schizosaccharomyces pombe)
Pkcdelta [cytosol] (Drosophila melanogaster)
pck2 [cytosol] (Schizosaccharomyces pombe)
prkcq [cytosol] (Danio rerio)
Prkcq [cytosol] (Mus musculus)
Prkcq [cytosol] (Rattus norvegicus)
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Investigational
ZINC - Metabolites
IntEnz
GeneCards
HPA
Ensembl
Pharos - Targets
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (8)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P06241 FYN  6 0.66 7
 UniProt:Q8IVH8 M4K3      0.639 4
 UniProt:O76003 GLRX3  1 0.602 5
 UniProt:Q05513 PRKCZ  5 0.581 3
 UniProt:Q00613 HSF1  11 0.544 2
 UniProt:Q05655 PRKCD  12 0.527 2
 UniProt:Q06187 BTK  6 0.524 2
 UniProt:P06239 LCK  4 0.499 2
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