Reactome | PRKCQ(355-706) [cytosol]

PRKCQ(355-706) [cytosol]

Stable Identifier

R-HSA-212514

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Protein kinase C, theta type fragment (355-706), nPKC-theta

Icon

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
9252332	Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis Datta, R, Kojima, H, Yoshida, K, Kufe, D	J Biol Chem	1997
9431985	The proteolytic cleavage of protein kinase C isotypes, which generates kinase and regulatory fragments, correlates with Fas-mediated and 12-O-tetradecanoyl-phorbol-13-acetate-induced apoptosis Mizuno, K, Noda, K, Araki, T, Imaoka, T, Kobayashi, Y, Akita, Y, Shimonaka, M, Kishi, S, Ohno, S	Eur J Biochem	1997

External Reference Information

External Reference

UniProt:Q04759 PRKCQ

Gene Names

PRKCQ, PRKCT

Chain

chain:1-706

Reference Genes

BioGPS Gene:5588 PRKCQ

COSMIC (genes):PRKCQ PRKCQ

CTD Gene:5588 PRKCQ

dbSNP Gene:5588 PRKCQ

ENSEMBL:ENSG00000065675 PRKCQ

HGNC:9410 PRKCQ

KEGG Gene (Homo sapiens):5588 PRKCQ

Monarch:5588 PRKCQ

NCBI Gene:5588 PRKCQ

OMIM:600448 PRKCQ

UCSC:Q04759 PRKCQ

Reference Transcript

Other Identifiers

0002940053

11728077_s_at

11747467_a_at

11750753_a_at

16711533

2081_s_at

210038_at

210039_s_at

3275955

3275956

3275957

3275958

3275959

3275960

3275963

3275967

3275969

3275971

3275972

3275977

3275978

3275979

3275981

3275987

3275989

3275990

3275991

3275995

3275997

3276002

3276010

3276011

38949_at

5588

7931930

A_23_P1374

GE79759

GE88182

GO:0000166

GO:0000902

GO:0001558

GO:0001772

GO:0002376

GO:0003674

GO:0004672

GO:0004674

GO:0004697

GO:0004698

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005737

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0006259

GO:0006355

GO:0006464

GO:0006468

GO:0006509

GO:0006950

GO:0006954

GO:0007155

GO:0007165

GO:0007411

GO:0008150

GO:0008219

GO:0008283

GO:0009058

GO:0016020

GO:0016235

GO:0016301

GO:0016310

GO:0016740

GO:0018105

GO:0030154

GO:0030168

GO:0032212

GO:0032740

GO:0032743

GO:0032753

GO:0034451

GO:0034641

GO:0035556

GO:0038095

GO:0040007

GO:0040011

GO:0042102

GO:0042592

GO:0043167

GO:0043226

GO:0045652

GO:0046627

GO:0046872

GO:0048856

GO:0048870

GO:0050852

GO:0050870

GO:0051092

GO:0051276

GO:0051973

GO:0060326

GO:0070233

GO:0090330

GO:1904355

GO:2000318

GO:2000570

HMNXSV003003840

HMNXSV003036575

Hs.211593.0.S2_3p_at

ILMN_1733421

L01087_at

PH_hs_0024719

PH_hs_0033184

TC10001014.hg

g558098_3p_a_at

Participates

as an output of

Caspase-mediated cleavage of PKC theta (Homo sapiens)

Other forms of this molecule

PRKCQ [photoreceptor disc membrane]

p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane]

PRKQC closed conformation [cytosol]

PRKCQ [plasma membrane]

p-Y90-PRKCQ [plasma membrane]

p-Y90,T538,S676,S695-PRKCQ [plasma membrane]

PRKCQ(1-354) [cytosol]

PRKCQ [cytosol]

Inferred To

PKC1 [cytosol] (Saccharomyces cerevisiae)

pck1 [cytosol] (Schizosaccharomyces pombe)

tpa-1 [cytosol] (Caenorhabditis elegans)

PRKCQ [cytosol] (Bos taurus)

PRKCQ [cytosol] (Canis familiaris)

PRKCQ [cytosol] (Sus scrofa)

Homologues of PRKCQ(355-706) [cytosol] (Schizosaccharomyces pombe)

Pkcdelta [cytosol] (Drosophila melanogaster)

pck2 [cytosol] (Schizosaccharomyces pombe)

prkcq [cytosol] (Danio rerio)

Prkcq [cytosol] (Mus musculus)

Prkcq [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001269573.1, NP_006248.1, NP_001310195.1, XP_006717528.1, XP_016871900.1, NP_001269574.1, XP_016871899.1, NP_001310194.1, NP_001229342.1

ZINC - World Drugs

KPCT_HUMAN

OpenTargets

ENSG00000065675

ZINC - FDA approved

KPCT_HUMAN

ZINC - Substances

KPCT_HUMAN

ZINC - Biogenic

KPCT_HUMAN

ZINC target

Q04759

PRO

Q04759

PDB

1XJD, 2ENZ, 2ENN, 4Q9Z, 4RA5, 5F9E, 2JED, 2ENJ

ZINC - Investigational

KPCT_HUMAN

ZINC - Metabolites

KPCT_HUMAN

IntEnz

2.7.11.13

GeneCards

Q04759

HPA

ENSG00000065675-PRKCQ

Ensembl

ENSP00000441752, ENSP00000263125, ENSG00000065675, ENST00000397176, ENSP00000380361, ENST00000539722, ENST00000263125

ZINC - Predictions - Purchasable

KPCT_HUMAN

HMDB Protein

HMDBP01849

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06241 FYN	6	MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) p-Y420-FYN [cytosol] (R-HSA-391821) FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410)	0.66	7
UniProt:Q8IVH8 M4K3			0.639	4
UniProt:O76003 GLRX3	1	GLRX3 [cytosol] (R-HSA-5691202)	0.602	5
UniProt:Q05513 PRKCZ	5	p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) p-T410-PRKCZ [cytosol] (R-HSA-437181) PRKCZ [cytosol] (R-HSA-58218) PRKCZ [cell junction] (R-HSA-2134483) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)	0.581	3
UniProt:Q00613 HSF1	11	p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) HSF1 [nucleoplasm] (R-HSA-5082385) hC36,103-HSF1 [cytosol] (R-HSA-4793916) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) HSF1 [cytosol] (R-HSA-3371452) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416)	0.544	2
UniProt:Q06187 BTK	6	p-Y223,Y551-BTK [cytosol] (R-HSA-2424454) Active BTK [cytosol] (R-HSA-8964323) p-Y551-BTK [cytosol] (R-HSA-2685603) p-Y551-BTK [plasma membrane] (R-HSA-9606165) p-Y223,Y551-BTK [plasma membrane] (R-HSA-984807) BTK [cytosol] (R-HSA-197948)	0.524	2
UniProt:P06239 LCK	4	p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940) LCK [cytosol] (R-HSA-167609) p-Y394-LCK [cytosol] (R-HSA-202308)	0.499	2

Cite Us!