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PRKCQ(355-706)
Stable Identifier
R-HSA-212514
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein kinase C, theta type fragment (355-706), nPKC-theta
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
Caspase-mediated cleavage of PKC theta (Homo sapiens)
PRKCQ(355-706) [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
9252332
Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis
J Biol Chem
1997
9431985
The proteolytic cleavage of protein kinase C isotypes, which generates kinase and regulatory fragments, correlates with Fas-mediated and 12-O-tetradecanoyl-phorbol-13-acetate-induced apoptosis
Eur J Biochem
1997
External Reference Information
External Reference
UniProt:Q04759 PRKCQ
Gene Names
PRKCQ, PRKCT
Chain
chain:1-706
Reference Genes
BioGPS Gene:5588 PRKCQ
COSMIC (genes):PRKCQ PRKCQ
CTD Gene:5588 PRKCQ
dbSNP Gene:5588 PRKCQ
ENSEMBL:ENSG00000065675 PRKCQ
HGNC:9410 PRKCQ
KEGG Gene (Homo sapiens):hsa:5588 PRKCQ
Monarch:5588 PRKCQ
NCBI Gene:5588 PRKCQ
OMIM:600448 PRKCQ
UCSC:Q04759 PRKCQ
Reference Transcript
RefSeq:XM_017016410.1 PRKCQ
RefSeq:NM_001242413.2 PRKCQ
RefSeq:XM_006717465.3 PRKCQ
RefSeq:NM_001282644.1 PRKCQ
RefSeq:XM_017016411.1 PRKCQ
RefSeq:NM_001323265.1 PRKCQ
RefSeq:NM_001282645.1 PRKCQ
RefSeq:NM_006257.4 PRKCQ
RefSeq:NM_001323266.1 PRKCQ
Other Identifiers
0002940053
04070+2.7.11.13
11728077_s_at
11747467_a_at
11750753_a_at
16711533
1XJD
2081_s_at
210038_at
210039_s_at
2ENJ
2ENN
2ENZ
2JED
3275956
3275957
3275958
3275959
3275960
3275963
3275967
3275969
3275971
3275972
3275977
3275978
3275979
3275981
3275987
3275989
3275990
3275991
3275995
3275997
3276002
3276010
38949_at
4Q9Z
4RA5
5588
5F9E
65279
73098
7931930
A_23_P1374
CCDS55701
CCDS60482
CCDS7079
ENSG00000065675
ENSP00000263125
ENSP00000380361
ENSP00000441752
ENST00000263125
ENST00000397176
ENST00000539722
EntrezGene:5588
g558098_3p_a_at
GE79759
GE88182
GO:0000166
GO:0001558
GO:0001772
GO:0002376
GO:0004672
GO:0004674
GO:0004697
GO:0005515
GO:0005524
GO:0005622
GO:0005737
GO:0005815
GO:0005829
GO:0005886
GO:0006355
GO:0006468
GO:0006509
GO:0006954
GO:0007411
GO:0016020
GO:0016235
GO:0016301
GO:0016310
GO:0016740
GO:0018105
GO:0030168
GO:0032212
GO:0032740
GO:0032753
GO:0035556
GO:0038095
GO:0042102
GO:0045086
GO:0045652
GO:0046627
GO:0046872
GO:0050852
GO:0050870
GO:0051092
GO:0051973
GO:0060326
GO:0070233
GO:0090330
GO:0097194
GO:1904355
GO:2000318
GO:2000570
HGNC:9410
HPA065279
HPA073098
Hs.211593.0.S2_3p_at
Hs.498570
ILMN_1733421
L01087_at
MIM:600448
NM_001242413
NM_001282644
NM_001282645
NM_001323265
NM_001323266
NM_001323267
NM_006257
NP_001229342
NP_001269573
NP_001269574
NP_001310194
NP_001310195
NP_001310196
NP_006248
PF00069
PF00130
PF00433
PH_hs_0024719
PH_hs_0033184
PR00008
PRKCQ
PRKCQ-201
PRKCQ-202
PRKCQ-203
SM00109
SM00133
SM00220
TC10001014.hg
uc001ijj.3
uc009xim.3
uc010qax.3
UPI000012DF74
UPI00004DC51A
UPI00017A701C
XM_005252496
XM_005252497
XM_006717465
XM_017016410
XM_017016411
XP_005252553
XP_005252554
XP_006717528
XP_016871899
XP_016871900
Participant Of
output
Caspase-mediated cleavage of PKC theta
Other forms of this molecule
PRKCQ [photoreceptor disc membrane]
PRKCQ(1-354) [cytosol]
p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane]
PRKQC closed conformation [cytosol]
PRKCQ [plasma membrane]
p-Y90,T538,S676,S695-PRKCQ [plasma membrane]
p-Y90-PRKCQ [plasma membrane]
PRKCQ [cytosol]
Inferred To
Homologues of PRKCQ(355-706) [cytosol] (Danio rerio)
PRKCQ(355-706) [cytosol] (Bos taurus)
PRKCQ(355-706) [cytosol] (Caenorhabditis elegans)
PRKCQ(355-706) [cytosol] (Canis familiaris)
PRKCQ(355-706) [cytosol] (Danio rerio)
PRKCQ(355-706) [cytosol] (Dictyostelium discoideum)
PRKCQ(355-706) [cytosol] (Drosophila melanogaster)
PRKCQ(355-706) [cytosol] (Gallus gallus)
PRKCQ(355-706) [cytosol] (Mus musculus)
PRKCQ(355-706) [cytosol] (Rattus norvegicus)
PRKCQ(355-706) [cytosol] (Saccharomyces cerevisiae)
PRKCQ(355-706) [cytosol] (Sus scrofa)
PRKCQ(355-706) [cytosol] (Taeniopygia guttata)
PRKCQ(355-706) [cytosol] (Xenopus tropicalis)
Cross References
RefSeq
XP_016871899.1
,
XP_006717528.1
,
NP_006248.1
,
NP_001310195.1
,
NP_001310194.1
,
NP_001269574.1
,
NP_001269573.1
,
NP_001229342.1
,
XP_016871900.1
Brenda
2.7.11.13
ZINC - World Drugs
KPCT_HUMAN
ZINC - FDA approved
KPCT_HUMAN
ZINC - Substances
KPCT_HUMAN
ZINC - Biogenic
KPCT_HUMAN
ZINC target
Q04759
PRO
Q04759
PDB
4RA5
,
5F9E
,
4Q9Z
,
2JED
,
2ENZ
,
2ENN
,
2ENJ
,
1XJD
ZINC - Metabolites
KPCT_HUMAN
GeneCards
Q04759
DOCK Blaster
2JED
,
1XJD
,
4Q9Z
,
5F9E
,
4RA5
ZINC - Predictions - Purchasable
KPCT_HUMAN
HMDB Protein
HMDBP01849
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06241 FYN
5
p-Y531-FYN [cytosol]
(R-HSA-391819)
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.66
7
UniProt:Q8IVH8 M4K3
0.639
4
UniProt:O76003 GLRX3
1
GLRX3 [cytosol]
(R-HSA-5691202)
0.602
5
UniProt:Q05513 PRKCZ
4
p-T410-PRKCZ [cytosol]
(R-HSA-437181)
PRKCZ [cell junction]
(R-HSA-2134483)
p-T410,T563-PRKCZ [cytosol]
(R-HSA-5218698)
PRKCZ [cytosol]
(R-HSA-58218)
0.581
3
UniProt:Q00613 HSF1
11
p-S307-HSF1 [cytosol]
(R-HSA-4793929)
p-S121-HSF1 [cytosol]
(R-HSA-4793906)
p-S303-HSF1 [cytosol]
(R-HSA-4793927)
p-S303,307-HSF1 [cytosol]
(R-HSA-4793922)
hC36,103-HSF1 [nucleoplasm]
(R-HSA-3371416)
Ac-K80-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5097238)
p-S326-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082355)
p-S230-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082361)
hC36,103-HSF1 [cytosol]
(R-HSA-4793916)
HSF1 [cytosol]
(R-HSA-3371452)
HSF1 [nucleoplasm]
(R-HSA-5082385)
0.544
2
UniProt:Q06187 BTK
4
p-Y551-BTK [cytosol]
(R-HSA-2685603)
p-Y223,Y551-BTK [cytosol]
(R-HSA-2424454)
p-Y223,Y551-BTK [plasma membrane]
(R-HSA-984807)
BTK [cytosol]
(R-HSA-197948)
0.524
2
UniProt:P06239 LCK
4
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.499
2
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