Reactome | Caspase-mediated cleavage of PKC theta

Caspase-mediated cleavage of PKC theta

Stable Identifier

R-HSA-201603

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Cleavage of PKCtheta by Caspase-3 induces nuclear fragmentation and lethality (Datta et al., 1997)

Literature References

PubMed ID	Title	Journal	Year
9431985	The proteolytic cleavage of protein kinase C isotypes, which generates kinase and regulatory fragments, correlates with Fas-mediated and 12-O-tetradecanoyl-phorbol-13-acetate-induced apoptosis Mizuno, K, Noda, K, Araki, T, Imaoka, T, Kobayashi, Y, Akita, Y, Shimonaka, M, Kishi, S, Ohno, S	Eur J Biochem	1997
9252332	Caspase-3-mediated cleavage of protein kinase C theta in induction of apoptosis Datta, R, Kojima, H, Yoshida, K, Kufe, D	J Biol Chem	1997