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PRKCQ [plasma membrane]
Stable Identifier
R-HSA-202346
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
PKC-theta (open conformation)
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
Change of PKC theta conformation (Homo sapiens)
PKC-theta (open): DAG [plasma membrane] (Homo sapiens)
PRKCQ [plasma membrane] (Homo sapiens)
Translocation of PKC theta to plasma membrane (Homo sapiens)
PKC-theta (open): DAG [plasma membrane] (Homo sapiens)
PRKCQ [plasma membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated NF-kB activation (Homo sapiens)
Phosphorylation of PKC-theta (Homo sapiens)
PKC-theta (open): DAG [plasma membrane] (Homo sapiens)
PRKCQ [plasma membrane] (Homo sapiens)
Translocation of PKC theta to plasma membrane (Homo sapiens)
PKC-theta (open): DAG [plasma membrane] (Homo sapiens)
PRKCQ [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q04759 PRKCQ
Gene Names
PRKCQ, PRKCT
Chain
chain:1-706
Reference Genes
BioGPS Gene:5588 PRKCQ
COSMIC (genes):PRKCQ PRKCQ
CTD Gene:5588 PRKCQ
dbSNP Gene:5588 PRKCQ
ENSEMBL:ENSG00000065675 PRKCQ
ENSEMBL_homo_sapiens_GENE:ENSG00000065675.16 PRKCQ
HGNC:9410 PRKCQ
KEGG Gene (Homo sapiens):5588 PRKCQ
Monarch:5588 PRKCQ
NCBI Gene:5588 PRKCQ
OMIM:600448 PRKCQ
UCSC:Q04759 PRKCQ
Reference Transcript
RefSeq:NM_001323265.1 PRKCQ
RefSeq:NM_001323266.1 PRKCQ
RefSeq:NM_006257.4 PRKCQ
RefSeq:XM_017016410.1 PRKCQ
RefSeq:XM_006717465.3 PRKCQ
RefSeq:XM_017016411.1 PRKCQ
RefSeq:NM_001242413.2 PRKCQ
RefSeq:NM_001282644.1 PRKCQ
RefSeq:NM_001282645.1 PRKCQ
Other Identifiers
11728077_s_at
11747467_a_at
11750753_a_at
16711533
2081_s_at
210038_PM_at
210038_at
210039_PM_s_at
210039_s_at
3275955
3275956
3275957
3275958
3275959
3275960
3275963
3275967
3275969
3275971
3275972
3275977
3275978
3275979
3275981
3275987
3275989
3275990
3275991
3275995
3275997
3276002
3276010
3276011
38949_at
5588
7931930
A_23_P1374
GE79759
GE88182
GO:0000166
GO:0001558
GO:0001772
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004697
GO:0005515
GO:0005524
GO:0005737
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006509
GO:0006954
GO:0007155
GO:0007411
GO:0012501
GO:0016020
GO:0016235
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030154
GO:0032200
GO:0032212
GO:0032740
GO:0032743
GO:0032753
GO:0034451
GO:0035556
GO:0035739
GO:0036211
GO:0038095
GO:0042060
GO:0042110
GO:0043226
GO:0046627
GO:0046872
GO:0048856
GO:0048870
GO:0050870
GO:0050896
GO:0051092
GO:0051973
GO:0060326
GO:0070233
GO:0080090
GO:0090330
GO:0106310
GO:0140096
GO:1904355
GO:2000318
GO:2000563
GO:2000570
HMNXSV003003840
HMNXSV003036575
Hs.211593.0.S2_3p_at
ILMN_1733421
L01087_at
PH_hs_0024719
PH_hs_0033184
TC10001014.hg
g558098_3p_a_at
Participates
as a component of
PKC-theta (open): DAG [plasma membrane] (Homo sapiens)
Other forms of this molecule
PRKCQ [photoreceptor disc membrane]
p-Y90,T219,T538,S676,S695-PRKCQ [plasma membrane]
PRKCQ(1-354) [cytosol]
PRKCQ(355-706) [cytosol]
PRKCQ [cytosol]
PRKQC closed conformation [cytosol]
p-Y90-PRKCQ [plasma membrane]
p-Y90,T538,S676,S695-PRKCQ [plasma membrane]
Inferred To
PRKCQ [plasma membrane]
(Bos taurus)
PRKCQ [plasma membrane]
(Caenorhabditis elegans)
PRKCQ [plasma membrane]
(Canis familiaris)
PRKCQ [plasma membrane]
(Dictyostelium discoideum)
PRKCQ [plasma membrane]
(Drosophila melanogaster)
PRKCQ [plasma membrane]
(Mus musculus)
PRKCQ [plasma membrane]
(Rattus norvegicus)
PRKCQ [plasma membrane]
(Saccharomyces cerevisiae)
PRKCQ [plasma membrane]
(Schizosaccharomyces pombe)
PRKCQ [plasma membrane]
(Sus scrofa)
Homologues of PRKCQ [plasma membrane]
(Dictyostelium discoideum)
Homologues of PRKCQ [plasma membrane]
(Schizosaccharomyces pombe)
Cross References
RefSeq
XP_006717528.1
,
NP_006248.1
,
NP_001229342.1
,
XP_016871899.1
,
NP_001269574.1
,
XP_016871900.1
,
NP_001310194.1
,
NP_001310195.1
,
NP_001269573.1
ZINC - World Drugs
KPCT_HUMAN
Guide to Pharmacology - Targets
1488
OpenTargets
ENSG00000065675
ZINC - FDA approved
KPCT_HUMAN
ZINC - Substances
KPCT_HUMAN
ZINC - Biogenic
KPCT_HUMAN
ZINC target
Q04759
PRO
Q04759
PDB
4RA5
,
4Q9Z
,
1XJD
,
2JED
,
2ENJ
,
2ENN
,
2ENZ
,
5F9E
ZINC - Investigational
KPCT_HUMAN
ZINC - Metabolites
KPCT_HUMAN
IntEnz
2.7.11.13
HPA
ENSG00000065675-PRKCQ
GeneCards
Q04759
Ensembl
ENST00000539722
,
ENSP00000441752
,
ENST00000263125
,
ENST00000397176
,
ENSG00000065675
,
ENSP00000263125
,
ENSP00000380361
Pharos - Targets
Q04759
ZINC - Predictions - Purchasable
KPCT_HUMAN
HMDB Protein
HMDBP01849
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.66
7
UniProt:Q8IVH8 M4K3
0.639
4
UniProt:O76003 GLRX3
1
GLRX3 [cytosol]
(R-HSA-5691202)
0.602
5
UniProt:Q05513 PRKCZ
5
p-T410,T563-PRKCZ [cytosol]
(R-HSA-5218698)
PRKCZ [cytosol]
(R-HSA-58218)
PRKCZ [cell junction]
(R-HSA-2134483)
p-T410-PRKCZ [cytosol]
(R-HSA-437181)
pS, p-T410-PRKCZ [cytosol]
(R-HSA-9632824)
0.581
3
UniProt:Q00613 HSF1
11
p-S121-HSF1 [cytosol]
(R-HSA-4793906)
p-S303-HSF1 [cytosol]
(R-HSA-4793927)
p-S307-HSF1 [cytosol]
(R-HSA-4793929)
p-S303,307-HSF1 [cytosol]
(R-HSA-4793922)
HSF1 [nucleoplasm]
(R-HSA-5082385)
hC36,103-HSF1 [cytosol]
(R-HSA-4793916)
p-S230-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082361)
Ac-K80-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5097238)
hC36,103-HSF1 [nucleoplasm]
(R-HSA-3371416)
p-S326-hC36,103-HSF1 [nucleoplasm]
(R-HSA-5082355)
HSF1 [cytosol]
(R-HSA-3371452)
0.544
2
UniProt:P17028 ZNF24
0.527
2
UniProt:O14523 C2C2L
0.527
2
UniProt:Q9H4E7 DEF6
1
DEF6 [cytosol]
(R-HSA-9691487)
0.527
2
UniProt:Q05655 PRKCD
12
PRKCD(1-676) [nucleoplasm]
(R-HSA-450606)
PRKCD(330-676) [extracellular region]
(R-HSA-6806199)
PRKCD(1-329) [extracellular region]
(R-HSA-6806226)
PRKCD(1-329) [azurophil granule lumen]
(R-HSA-6799219)
PRKCD(330-676) [azurophil granule lumen]
(R-HSA-6799221)
p-T507-PRKCD [cytosol]
(R-HSA-5218746)
p-T507,S645,S664-PRKCD [cytosol]
(R-HSA-5218734)
active p-T507,S645,S664-PRKCD [plasma membrane]
(R-HSA-5607635)
p-T507,S645,S664-PRKCD(1-676) [plasma membrane]
(R-HSA-198294)
PRKCD(330-676) [cytosol]
(R-HSA-212551)
PRKCD(1-329) [cytosol]
(R-HSA-212547)
PRKCD [cytosol]
(R-HSA-58200)
0.527
2
UniProt:Q06187 BTK
6
p-Y223,Y551-BTK [cytosol]
(R-HSA-2424454)
Active BTK [cytosol]
(R-HSA-8964323)
p-Y551-BTK [cytosol]
(R-HSA-2685603)
BTK [cytosol]
(R-HSA-197948)
p-Y551-BTK [plasma membrane]
(R-HSA-9606165)
p-Y223,Y551-BTK [plasma membrane]
(R-HSA-984807)
0.524
2
UniProt:P06239 LCK
4
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.499
2
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