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p75NTR recruits signalling complexes
Stable Identifier
R-HSA-209543
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
p75NTR recruits signalling complexes (Homo sapiens)
General
SBML
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BioPAX
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SBGN
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NF-kB activation involves recruitment at the cell membrane of several proteins such as RIP2, MYD88, IRAK1, TRAF6, p62 and atypical PKC by the NGF:p75NTR complex.
Participants
Events
p75NTR interacts with RIP2
(Homo sapiens)
p75NTR interacts with IRAK:MYD88
(Homo sapiens)
IRAK is activated
(Homo sapiens)
IRAK interacts with TRAF6
(Homo sapiens)
MYD88 dissociates
(Homo sapiens)
p62 is recruited and forms a complex with TRAF6
(Homo sapiens)
TRAF6 is auto-ubiquitinated
(Homo sapiens)
p62 recruits an atypical PKC
(Homo sapiens)
IKK-beta is recruited
(Homo sapiens)
Participates
as an event of
p75NTR signals via NF-kB (Homo sapiens)
Orthologous Events
p75NTR recruits signalling complexes (Bos taurus)
p75NTR recruits signalling complexes (Canis familiaris)
p75NTR recruits signalling complexes (Danio rerio)
p75NTR recruits signalling complexes (Gallus gallus)
p75NTR recruits signalling complexes (Mus musculus)
p75NTR recruits signalling complexes (Rattus norvegicus)
p75NTR recruits signalling complexes (Sus scrofa)
p75NTR recruits signalling complexes (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000477
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Friedman, WJ (2008-05-20)
Chao, MV (2008-05-28)
Created
Jassal, B (2007-12-19)
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