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IRAK interacts with TRAF6
Stable Identifier
R-HSA-193695
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
p75NTR recruits signalling complexes (Homo sapiens)
IRAK interacts with TRAF6 (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Neurotrophin binding to p75NTR leads to recruitment of TRAF6. This protein is an E3 ubiquitin ligase, which, together with an E2 Ubiquitin conjugating enzyme, mediates the assembly of lysine 63-linked polyubiquitin chains and their attachment to a lysine of a substrate protein. Activation of IRAK1 promotes recruitment of TRAF6. TRAF6 is able to bind to p75NTR (juxtamembrane region, residues 113-128), IRAK1 (N-terminal residues 1-198 and C-terminal residues 523-618), and MYD88. It might be recruited through the MYD88:IRAK1 complex.
Literature References
PubMed ID
Title
Journal
Year
9915784
Association of the p75 neurotrophin receptor with TRAF6
Orlinick, JR
,
Khursigara, G
,
Chao, MV
J Biol Chem
1999
Participants
Input
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane]
(Homo sapiens)
TRAF6 [cytosol]
(Homo sapiens)
Output
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane]
(Homo sapiens)
Participates
as an event of
p75NTR recruits signalling complexes (Homo sapiens)
Orthologous Events
IRAK interacts with TRAF6 (Bos taurus)
IRAK interacts with TRAF6 (Canis familiaris)
IRAK interacts with TRAF6 (Danio rerio)
IRAK interacts with TRAF6 (Gallus gallus)
IRAK interacts with TRAF6 (Mus musculus)
IRAK interacts with TRAF6 (Rattus norvegicus)
IRAK interacts with TRAF6 (Sus scrofa)
IRAK interacts with TRAF6 (Xenopus tropicalis)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Friedman, WJ (2008-05-20)
Chao, MV (2008-05-28)
Created
Jassal, B (2007-02-23)
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