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p75NTR interacts with RIP2
Stable Identifier
R-HSA-193656
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
p75NTR recruits signalling complexes (Homo sapiens)
p75NTR interacts with RIP2 (Homo sapiens)
General
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The RIP2 (receptor-interacting protein-2) kinase is a mediator of NGF-dependent NF-kB activity. It contains a serine/threonine kinase domain and a caspase recruitment domain (CARD) at the C terminus. It binds to the death domain of p75NTR via its CARD domain in an NGF-dependent manner. RIP2 may also bind TRAF proteins, suggesting the existence of complexes of TRAF and RIP2 proteins with the p75 receptor. RIP2 is also able to interact with p62. It is highly expressed in Schwann cells.
Literature References
PubMed ID
Title
Journal
Year
11487608
A prosurvival function for the p75 receptor death domain mediated via the caspase recruitment domain receptor-interacting protein 2
Moffett, H
,
Khursigara, G
,
Yano, H
,
Bertin, J
,
DiStefano, PS
,
Chao, MV
J Neurosci
2001
Participants
Input
mature NGF homodimer:p75NTR [plasma membrane]
(Homo sapiens)
RIPK2 [cytosol]
(Homo sapiens)
Output
NGF:p75NTR:RIP2 [plasma membrane]
(Homo sapiens)
Participates
as an event of
p75NTR recruits signalling complexes (Homo sapiens)
Orthologous Events
p75NTR interacts with RIP2 (Bos taurus)
p75NTR interacts with RIP2 (Canis familiaris)
p75NTR interacts with RIP2 (Danio rerio)
p75NTR interacts with RIP2 (Gallus gallus)
p75NTR interacts with RIP2 (Mus musculus)
p75NTR interacts with RIP2 (Rattus norvegicus)
p75NTR interacts with RIP2 (Sus scrofa)
p75NTR interacts with RIP2 (Xenopus tropicalis)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Friedman, WJ (2008-05-20)
Chao, MV (2008-05-28)
Created
Jassal, B (2007-02-23)
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