The RIP2 (receptor-interacting protein-2) kinase is a mediator of NGF-dependent NF-kB activity. It contains a serine/threonine kinase domain and a caspase recruitment domain (CARD) at the C terminus. It binds to the death domain of p75NTR via its CARD domain in an NGF-dependent manner. RIP2 may also bind TRAF proteins, suggesting the existence of complexes of TRAF and RIP2 proteins with the p75 receptor. RIP2 is also able to interact with p62. It is highly expressed in Schwann cells.