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p62 recruits an atypical PKC
Stable Identifier
R-HSA-193684
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
p75NTR recruits signalling complexes (Homo sapiens)
p62 recruits an atypical PKC (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The atypical protein kinase C-iota isoform (aPKC-i) is recruited to the p75NTR receptor complex by p62 and becomes active. p62 recruits aPKC both via TRAF6 and RIP2.
Literature References
PubMed ID
Title
Journal
Year
11244088
The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor
Seibenhener, ML
,
Moscat, J
,
Wooten, MW
,
Barker, PA
,
Diaz-Meco, MT
,
Mamidipudi, V
J Biol Chem
2001
Participants
Input
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane]
(Homo sapiens)
PRKCI [cytosol]
(Homo sapiens)
Output
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane]
(Homo sapiens)
Participates
as an event of
p75NTR recruits signalling complexes (Homo sapiens)
Orthologous Events
p62 recruits an atypical PKC (Bos taurus)
p62 recruits an atypical PKC (Canis familiaris)
p62 recruits an atypical PKC (Danio rerio)
p62 recruits an atypical PKC (Gallus gallus)
p62 recruits an atypical PKC (Mus musculus)
p62 recruits an atypical PKC (Rattus norvegicus)
p62 recruits an atypical PKC (Sus scrofa)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Friedman, WJ (2008-05-20)
Chao, MV (2008-05-28)
Created
Jassal, B (2007-02-23)
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