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p75NTR signals via NF-kB
Stable Identifier
R-HSA-193639
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
General
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The NF-kB pathway is an important pro-survival signalling pathway activated by mature NGF, but not BDNF or NT-3, through p75NTR. It is unclear whether TRKA activity also affects NF-kB activation.
Literature References
PubMed ID
Title
Journal
Year
16997282
NF-kappaB functions in the nervous system: from development to disease
Memet, S
Biochem Pharmacol
2006
Participants
Events
p75NTR recruits signalling complexes
(Homo sapiens)
NF-kB is activated and signals survival
(Homo sapiens)
Participates
as an event of
p75 NTR receptor-mediated signalling (Homo sapiens)
Event Information
Go Biological Process
negative regulation of apoptotic process (0043066)
Orthologous Events
p75NTR signals via NF-kB (Bos taurus)
p75NTR signals via NF-kB (Canis familiaris)
p75NTR signals via NF-kB (Danio rerio)
p75NTR signals via NF-kB (Drosophila melanogaster)
p75NTR signals via NF-kB (Gallus gallus)
p75NTR signals via NF-kB (Mus musculus)
p75NTR signals via NF-kB (Rattus norvegicus)
p75NTR signals via NF-kB (Sus scrofa)
p75NTR signals via NF-kB (Xenopus tropicalis)
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Friedman, WJ (2008-05-20)
Chao, MV (2008-05-28)
Created
Jassal, B (2007-02-23)
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