p75NTR interacts with IRAK:MYD88

Stable Identifier
R-HSA-193686
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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p75NTR interacts with IRAK:MYD88
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The serine/threonine kinase IRAK (interleukin-1 receptor-associated kinase) is necessary for NF-kB activation. Under basal conditions, IRAK is not bound to the p75 receptor, and stays inactive in the cytoplasm. It associates with p75NTR following neurotrophin binding. MYD88 functions as an adapter, by recruiting IRAK to the p75 receptor. Upon stimulation with NGF, a MYD88: IRAK1 complex quickly forms that is recruited to p75NTR.
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Inferred From
p75NTR interacts with Irak:Myd88 (Rattus norvegicus)
Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-02-23)
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