Reactome | IKK-beta is recruited

IKK-beta is recruited

Stable Identifier

R-HSA-193641

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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NGF stimulation results in recruitment of IKK-beta (Inhibitor of nuclear factor kappa-B kinase subunit beta) to the p75NTR receptor complex. IKK-beta recruitment involves p62 (Wooten et al. 2001, Cao et al. 1996a, et al. 1996b ).

Literature References

PubMed ID	Title	Journal	Year
8599092	IRAK: a kinase associated with the interleukin-1 receptor Cao, Z, Henzel, WJ, Gao, X	Science	1996
8837778	TRAF6 is a signal transducer for interleukin-1 Cao, Z, Xiong, J, Takeuchi, M, Kurama, T, Goeddel, DV	Nature	1996
11244088	The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor Wooten, MW, Seibenhener, ML, Mamidipudi, V, Diaz-Meco, MT, Barker, PA, Moscat, J	J Biol Chem	2001