TRAF6 is auto-ubiquitinated

Stable Identifier
R-HSA-209566
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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TRAF6 is auto-ubiquitinated
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The activity of TRAF6 is regulated by autoubiquitination. This process, in turn, is regulated by p62. Cells devoid of p62 exhibit low basal TRAF6 polyubiquitination. When p62 is expressed, auto-ubiquitination of TRAF6 is enhanced. The details curated in this event represent the ubiquitination of TRAF6, even as ubiquitin is shown as 1 stoichiometrically.
Literature References
PubMed ID Title Journal Year
15465037 The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination

Zhang, B, Zhu, J, Yang, K, Diao, L, Tang, Y, Wang, C, Sun, S

Biochem Biophys Res Commun 2004
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Authored
Nasi, S  (2006-10-10)
Annibali, D  (2006-10-10)
Reviewed
Friedman, WJ  (2008-05-20)
Chao, MV  (2008-05-28)
Created
Jassal, B  (2007-12-19)
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