Reactome | TRAF6 is auto-ubiquitinated

TRAF6 is auto-ubiquitinated

Stable Identifier

R-HSA-209566

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

plasma membrane

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The activity of TRAF6 is regulated by autoubiquitination. This process, in turn, is regulated by p62. Cells devoid of p62 exhibit low basal TRAF6 polyubiquitination. When p62 is expressed, auto-ubiquitination of TRAF6 is enhanced. The details curated in this event represent the ubiquitination of TRAF6, even as ubiquitin is shown as 1 stoichiometrically.

Literature References

PubMed ID	Title	Journal	Year
15465037	The coiled-coil domain of TRAF6 is essential for its auto-ubiquitination Yang, K, Zhu, J, Sun, S, Tang, Y, Zhang, B, Diao, L, Wang, C	Biochem Biophys Res Commun	2004