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mature NGF homodimer:p75NTR [plasma membrane]
Stable Identifier
R-HSA-205123
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NADE modulates death signalling (Homo sapiens)
14-3-3epsilon attentuates NADE-related apoptosis (Homo sapiens)
NGF ligand:p75NTR:NADE:14-3-3epsilon [plasma membrane] (Homo sapiens)
NGF:p75NTR:NADE [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
NGF:p75NTR:NADE [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
p75NTR binds to NADE (Homo sapiens)
NGF:p75NTR:NADE [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
p75NTR:NADE promotes caspase2/3 activation (Homo sapiens)
NGF:p75NTR:NADE [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
NGF:p75NTR complex binds to NRAGE (Homo sapiens)
NGF:p75NTR:NRAGE [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
NRAGE activates JNK (Homo sapiens)
NGF:p75NTR:NRAGE [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
NRAGE sequesters CHE1 in the cytoplasm (Homo sapiens)
NGF ligand:p75NTR:NRAGE:CHE1 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
NGF:p75NTR:NRAGE [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
NRIF signals cell death from the nucleus (Homo sapiens)
NRIF and TRAF6 may activate JNK (Homo sapiens)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:NRIF [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
NRIF binds to p75NTR (Homo sapiens)
NGF ligand:p75NTR:NRIF [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
TRAF6 binds to p75NTR:NRIF (Homo sapiens)
NGF ligand:p75NTR:NRIF [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:NRIF [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Homo sapiens)
NGF ligand:p75NTR:NRIF:TRAF6 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:NRIF [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
Ceramide signalling (Homo sapiens)
Sphingomyelinase is activated by the NGF:p75NTR complex (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
NFG and proNGF binds to p75NTR (Homo sapiens)
NGF homodimer binds to p75NTR (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
p75NTR negatively regulates cell cycle via SC1 (Homo sapiens)
PRDM4 (SC1) binds to p75NTR (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
p75NTR signals via NF-kB (Homo sapiens)
NF-kB is activated and signals survival (Homo sapiens)
IKKbeta is activated (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
IKKbeta phosphorylates IkB causing NF-kB to dissociate (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
p75NTR recruits signalling complexes (Homo sapiens)
IKK-beta is recruited (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:IKK-beta [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
IRAK interacts with TRAF6 (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
IRAK is activated (Homo sapiens)
NGF ligand:p75NTR:IRAK1:MYD88 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
MYD88 dissociates (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:MYD88:TRAF6 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
TRAF6 is auto-ubiquitinated (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
p62 is recruited and forms a complex with TRAF6 (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
p62 recruits an atypical PKC (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:aPKCi [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
p75NTR interacts with IRAK:MYD88 (Homo sapiens)
NGF ligand:p75NTR:IRAK1:MYD88 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
p75NTR interacts with RIP2 (Homo sapiens)
NGF:p75NTR:RIP2 [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
mature NGF homodimer:p75NTR [plasma membrane] (Homo sapiens)
Participants
components
mature beta-NGF homodimer [extracellular region]
(Homo sapiens)
NGFR [plasma membrane]
(Homo sapiens)
Participates
as a component of
NGF ligand:p75NTR:Phospho-IRAK1:polyubiquitinated TRAF6:p62 [plasma membrane] (Homo sapiens)
NGF:p75NTR:RIP2 [plasma membrane] (Homo sapiens)
NGF:p75NTR:NADE [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:NRAGE:CHE1 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:NRIF [plasma membrane] (Homo sapiens)
NGF:p75NTR:NRAGE [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:IRAK1:MYD88 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:p-IRAK1:MYD88 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6 [plasma membrane] (Homo sapiens)
NGF ligand:p75NTR:Phospho-IRAK1:TRAF6:p62:Phospho-IKK-beta [plasma membrane] (Homo sapiens)
as an input of
p75NTR interacts with RIP2 (Homo sapiens)
PRDM4 (SC1) binds to p75NTR (Homo sapiens)
p75NTR binds to NADE (Homo sapiens)
NRIF binds to p75NTR (Homo sapiens)
NGF:p75NTR complex binds to NRAGE (Homo sapiens)
p75NTR interacts with IRAK:MYD88 (Homo sapiens)
as an output of
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6 (Homo sapiens)
NGF homodimer binds to p75NTR (Homo sapiens)
Inferred To
mature NGF homodimer:p75NTR [plasma membrane]
(Bos taurus)
mature NGF homodimer:p75NTR [plasma membrane]
(Canis familiaris)
mature NGF homodimer:p75NTR [plasma membrane]
(Danio rerio)
mature NGF homodimer:p75NTR [plasma membrane]
(Gallus gallus)
mature NGF homodimer:p75NTR [plasma membrane]
(Mus musculus)
mature NGF homodimer:p75NTR [plasma membrane]
(Rattus norvegicus)
mature NGF homodimer:p75NTR [plasma membrane]
(Sus scrofa)
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