NGF:p75NTR complex binds to NRAGE

Stable Identifier
R-HSA-205115
Type
Reaction [binding]
Species
Homo sapiens
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NRAGE (neurotrophin receptor-interacting MAGE homolog), a member of the MAGE family of proteins, is a cytoplasmic protein that mediates neurotrophin-induced cell death. NRAGE binding is stimulated following NGF (or proNGF) binding to p75NTR. Some studies indicate that NRAGE expression is limited to proliferative neural populations, whereas others indicate its presence in differentiated neurons in hippocampus. Another MAGE protein, Necdin, was reported to interact with p75NTR and affect cell death.

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