gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6

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R-HSA-205112
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Reaction
Species
Homo sapiens
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Neurotrophin or proneurotrophin signalling promotes p75NTR cleavage by gamma-secretase, allowing the release of p75 ICD and NRIF. This mechanism was shown in sympathetic neurons.
Gamma-secretase can be activated in a number of ways, including signalling via p75NTR. The phorbol esther PMA induces p75 cleavage, followed by NRIF nuclear translocation, after 30 min. Neurotrophin binding to p75, instead, triggers the same events only after 12 h.

Literature References
PubMed ID Title Journal Year
16630834 Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons

Kenchappa, RS, Carter, BD, Zampieri, N, Hempstead, BL, Barker, PA, Teng, HK, Chao, MV

Neuron 2006
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Catalyst Activity

peptidase activity of gamma-secretase complex [plasma membrane]

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