Reactome | gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6

gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6

Stable Identifier

R-HSA-205112

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6

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Neurotrophin or proneurotrophin signalling promotes p75NTR cleavage by gamma-secretase, allowing the release of p75 ICD and NRIF. This mechanism was shown in sympathetic neurons.
Gamma-secretase can be activated in a number of ways, including signalling via p75NTR. The phorbol esther PMA induces p75 cleavage, followed by NRIF nuclear translocation, after 30 min. Neurotrophin binding to p75, instead, triggers the same events only after 12 h.

Literature References

PubMed ID	Title	Journal	Year
16630834	Ligand-dependent cleavage of the P75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons Kenchappa, RS, Carter, BD, Zampieri, N, Hempstead, BL, Barker, PA, Teng, HK, Chao, MV	Neuron	2006