NRIF is a ubiquitously expressed zinc finger protein of the Kruppel family that may transduce cell death signals during development and functions in association with TRAF6 to induce activation of JNK. NRIF-induced cell death through p75NTR requires p53 and NRIF nuclear translocation, which is modulated by TRAF6-mediated polyubiquitination of NRIF at lysine 63.
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