p-8Y-FGFR2 K660N [plasma membrane]

Stable Identifier
R-HSA-2033301
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
17803937 A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases

Chen, H, Ma, J, Li, W, Eliseenkova, AV, Xu, C, Neubert, TA, Miller, WT, Mohammadi, M

Mol Cell 2007
External Reference Information
External Reference
UniProt:P21802 FGFR2
Gene Names
FGFR2, BEK, KGFR, KSAM
Chain
signal peptide:1-21, chain:22-821
Reference Genes
BioGPS Gene:2263 FGFR2
COSMIC - genes:FGFR2 FGFR2
CTD Gene:2263 FGFR2
dbSNP Gene:2263 FGFR2
ENSEMBL:ENSG00000066468 FGFR2
HGNC:3689 FGFR2
KEGG:hsa:2263 FGFR2
Monarch:2263 FGFR2
NCBI Gene:2263 FGFR2
OMIM:176943 FGFR2
UCSC:P21802 FGFR2
Reference Transcript
Participates
as a component of
Other forms of this molecule
FGFR2 IIIa TM [extracellular region]
FGFR2 [plasma membrane]
FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane]
FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane]
FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane]
FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane]
FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane]
FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane]
FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane]
FGFR2 N549H [plasma membrane]
FGFR2 N549K [plasma membrane]
FGFR2 K660N [plasma membrane]
p-8Y-FGFR2 K660M [plasma membrane]
p-8Y-FGFR2 K660E [plasma membrane]
phosphorylated FGFR2 L764Hfs*4 [plasma membrane]
p-8Y-FGFR2 W290C [plasma membrane]
p-8Y-FGFR2 S267P [plasma membrane]
p-8Y-FGFR2 [plasma membrane]
p-8Y-FGFR2 N549K [plasma membrane]
p-8Y-FGFR2 N549H [plasma membrane]
p-6Y-FGFR2(22-767)-CCAR(51-923) fusion [plasma membrane]
p-6Y-FGFR2(22-767)-CASP7(1-303) fusion [plasma membrane]
p-6Y-FGFR2(22-767)-AFF3(292-1226) fusion [plasma membrane]
p-6Y-FGFR2(22-767)-OFD1(38-1012) fusion [plasma membrane]
p-6Y-FGFR2(22-767)-AHCYL1(108-530) fusion [plasma membrane]
p-6Y-FGFR2(2-822)-CIT(927-2027) fusion [plasma membrane]
p-6Y-FGFR2(22-768)-BICC1(80-974) fusion [plasma membrane]
p-6Y-FGFR2(22-767)-CCDC6(102-474) fusion [plasma membrane]
FGFR2 W290C [plasma membrane]
FGFR2 L764Hfs*4 [plasma membrane]
FGFR2 S267P [plasma membrane]
FGFR2 K660E [plasma membrane]
FGFR2 K660M [plasma membrane]
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
L-lysine 660 replaced with L-asparagine
Coordinate
660
PsiMod
L-asparagine residue [MOD:00012]
A protein modification that effectively converts a source amino acid residue to an L-asparagine.
L-lysine removal [MOD:01642]
A protein modification that effectively removes or replaces an L-lysine.
Disease
Name Identifier Synonyms
Crouzon syndrome DOID:2339 Craniofacial Dysostosis
female reproductive endometrioid cancer DOID:3001 endometrioid tumor (morphologic abnormality), endometrioid neoplasm
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
bone development disease DOID:0080006
Cross References
RefSeq
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ENSEMBL
Mondo
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
PDB
ZINC - Investigational
COSMIC
IntEnz
GeneCards
HPA
Pharos - Targets
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (31)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P09038 FGF2  1 0.779 5
 UniProt:P51812 RPS6KA3  7 0.745 5
 UniProt:P62993 GRB2  1 0.735 6
 ChEBI:73280 SSR      0.683 8
 UniProt:P05230 FGF1  1 0.675 3
 UniProt:P11362 FGFR1  9 0.623 3
 UniProt:O15520 FGF10  1 0.571 2
 UniProt:P06734 FCER2  1 0.558 2
 UniProt:P19174 PLCG1  6 0.528 3
 UniProt:Q3MIR4 CC50B      0.527 2
 UniProt:O60637 TSN3      0.527 2
 UniProt:Q96LL9 DJC30      0.527 2
 UniProt:Q6P047 CH074      0.527 2
 UniProt:Q99732 LITAF      0.527 2
 UniProt:Q8N7X8 SIGL1      0.527 2
 UniProt:Q5T9A4 ATAD3B  3 0.527 2
 UniProt:Q96HB5 CC120      0.527 2
 UniProt:Q8IWX8 CHERP  1 0.527 2
 UniProt:Q92551 IP6K1  2 0.527 2
 UniProt:Q6P995 F171B      0.527 2
 UniProt:P34741 SDC2  20 0.527 2
 UniProt:Q92575 UBXN4      0.527 2
 UniProt:Q96L94 SNX22      0.527 2
 UniProt:P01033 TIMP1  4 0.527 2
 UniProt:Q96G30 MRAP2      0.527 2
 UniProt:P55899 FCGRN      0.527 2
 UniProt:Q5TF58 IFFO2      0.527 2
 UniProt:Q06124 PTPN11  4 0.519 2
 UniProt:Q9ULH0 KIDINS220  2 0.483 2
 UniProt:Q9UBH6 S53A1      0.483 2
 UniProt:Q86VI4 LAP4B      0.463 2
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