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TNC [extracellular region]
Stable Identifier
R-HSA-215968
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Tenascin, TN-C
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
ECM proteoglycans (Homo sapiens)
TNC binds Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 (Homo sapiens)
TNC:Integrin alphaVbeta3, alphaVbeta6, alpha2beta1, alpha7beta1, alpha8beta1, alpha9beta1, alphaXbeta1 [plasma membrane] (Homo sapiens)
Tenascin-C hexamer [extracellular region] (Homo sapiens)
TNC [extracellular region] (Homo sapiens)
Tenascin-C hexamer [extracellular region] (Homo sapiens)
TNC [extracellular region] (Homo sapiens)
Tenascins C, R, (X, N) bind fibronectin matrix (Homo sapiens)
Tenascins C, R, (X, N) [extracellular region] (Homo sapiens)
Tenascin-C hexamer [extracellular region] (Homo sapiens)
TNC [extracellular region] (Homo sapiens)
Tenascins C, R, (X, N):Fibronectin matrix [extracellular region] (Homo sapiens)
Tenascins C, R, (X, N) [extracellular region] (Homo sapiens)
Tenascin-C hexamer [extracellular region] (Homo sapiens)
TNC [extracellular region] (Homo sapiens)
Tenascins C, R, (X, N) bind lecticans (Homo sapiens)
Tenascins C, R, (X, N) [extracellular region] (Homo sapiens)
Tenascin-C hexamer [extracellular region] (Homo sapiens)
TNC [extracellular region] (Homo sapiens)
Tenascins C, R, (X, N):Lecticans [extracellular region] (Homo sapiens)
Tenascins C, R, (X, N) [extracellular region] (Homo sapiens)
Tenascin-C hexamer [extracellular region] (Homo sapiens)
TNC [extracellular region] (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
Interaction of integrin alpha8beta1 with Tenascin-C (Homo sapiens)
Integrin alpha8beta1:Tenascin-C hexamer [plasma membrane] (Homo sapiens)
Tenascin-C hexamer [extracellular region] (Homo sapiens)
TNC [extracellular region] (Homo sapiens)
Tenascin-C hexamer [extracellular region] (Homo sapiens)
TNC [extracellular region] (Homo sapiens)
Interaction of integrin alpha9beta1 with Tenascin-C (Homo sapiens)
Integrin alpha9beta1:Tenascin-C hexamer [plasma membrane] (Homo sapiens)
Tenascin-C hexamer [extracellular region] (Homo sapiens)
TNC [extracellular region] (Homo sapiens)
Tenascin-C hexamer [extracellular region] (Homo sapiens)
TNC [extracellular region] (Homo sapiens)
Interaction of integrin alphaVbeta3 with Tenascin (Homo sapiens)
Integrin alphaVbeta3:Tenascin [plasma membrane] (Homo sapiens)
TNC [extracellular region] (Homo sapiens)
TNC [extracellular region] (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Syndecan interactions (Homo sapiens)
TNC binds Syndecan-3 (Homo sapiens)
TNC [extracellular region] (Homo sapiens)
TNC:Syndecan-3 [plasma membrane] (Homo sapiens)
TNC [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P24821 TNC
Gene Names
TNC, HXB
Chain
signal peptide:1-22, chain:23-2201
Reference Genes
BioGPS Gene:3371 TNC
COSMIC (genes):TNC TNC
CTD Gene:3371 TNC
dbSNP Gene:3371 TNC
ENSEMBL:ENSG00000041982 TNC
ENSEMBL_homo_sapiens_GENE:ENSG00000041982.17 TNC
HGNC:5318 TNC
KEGG Gene (Homo sapiens):3371 TNC
Monarch:3371 TNC
NCBI Gene:3371 TNC
OMIM:187380 TNC
UCSC:P24821 TNC
Reference Transcript
RefSeq:NM_002160.3 TNC
RefSeq:XM_005251975.3 TNC
RefSeq:XM_005251972.3 TNC
RefSeq:XM_011518629.2 TNC
RefSeq:XM_005251974.3 TNC
Other Identifiers
11716062_a_at
11716063_at
11747935_a_at
11752009_a_at
17097661
201645_PM_at
201645_at
237169_PM_at
237169_at
3222171
3222172
3222173
3222174
3222175
3222176
3222177
3222181
3222183
3222184
3222186
3222187
3222188
3222190
3222192
3222193
3222194
3222195
3222198
3222205
3222210
3222212
3222214
3222215
3222216
3222219
3222220
3222221
3222222
3222225
3222226
3222227
3222228
3222229
3222230
3222231
3222234
3222235
3222253
3222254
3222255
32818_at
3371
75075_at
8163637
GE62327
GO:0001558
GO:0001649
GO:0002009
GO:0005178
GO:0005198
GO:0005201
GO:0005515
GO:0005576
GO:0005604
GO:0005614
GO:0005615
GO:0005783
GO:0005788
GO:0005925
GO:0006954
GO:0007155
GO:0007162
GO:0007528
GO:0008284
GO:0009611
GO:0009612
GO:0010628
GO:0014012
GO:0016020
GO:0022414
GO:0023052
GO:0030154
GO:0030155
GO:0030312
GO:0030334
GO:0031012
GO:0031175
GO:0034330
GO:0042475
GO:0043226
GO:0045471
GO:0045545
GO:0048856
GO:0048870
GO:0050727
GO:0060447
GO:0060739
GO:0060740
GO:0062023
GO:0071300
GO:0071305
GO:0071774
GO:0071799
GO:0090733
GO:0098966
HMNXSV003048849
Hs.135261.0.A1_3p_at
ILMN_1719759
ILMN_2145670
PH_hs_0035499
TC09001517.hg
X78565_at
g4504548_3p_at
Participates
as a component of
TNC:Syndecan-3 [plasma membrane] (Homo sapiens)
Integrin alphaVbeta3:Tenascin [plasma membrane] (Homo sapiens)
Tenascin-C hexamer [extracellular region] (Homo sapiens)
as an input of
TNC binds Syndecan-3 (Homo sapiens)
Interaction of integrin alphaVbeta3 with Tenascin (Homo sapiens)
Other forms of this molecule
p-TNC [endoplasmic reticulum lumen]
TNC [endoplasmic reticulum lumen]
Inferred To
sadA [extracellular region]
(Dictyostelium discoideum)
TNN [extracellular region]
(Sus scrofa)
tnc [extracellular region]
(Xenopus tropicalis)
tncb [extracellular region]
(Danio rerio)
Homologues of TNC [extracellular region]
(Gallus gallus)
Homologues of TNC [extracellular region]
(Sus scrofa)
TNC [extracellular region]
(Bos taurus)
TNC [extracellular region]
(Caenorhabditis elegans)
TNC [extracellular region]
(Canis familiaris)
TNC [extracellular region]
(Gallus gallus)
TNC [extracellular region]
(Sus scrofa)
Tnc [extracellular region]
(Mus musculus)
Tnc [extracellular region]
(Rattus norvegicus)
Cross References
RefSeq
XP_005252032.1
,
XP_005252029.1
,
XP_011516931.1
,
NP_002151.2
,
XP_005252031.1
OpenTargets
ENSG00000041982
HPA
ENSG00000041982-TNC
GeneCards
P24821
Ensembl
ENST00000350763
,
ENSG00000041982
,
ENST00000537320
,
ENSP00000443478
,
ENSP00000265131
PRO
P24821
Pharos - Targets
P24821
Orphanet
22607
PDB
8FN8
,
5R5T
,
5R61
,
5R5W
,
5R5Z
,
6BRB
,
5R60
,
1TEN
,
5R5V
,
5R63
,
5R5Y
,
8FNB
,
5R5U
,
5R62
,
6QNV
,
5R5X
,
2RB8
,
2RBL
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P20908 COL5A1
20
3x4Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023553)
3x4Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023664)
GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023513)
GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023628)
3x4Hyp-3Hyp-GalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023564)
3x4Hyp-3Hyp-GlcGalHyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2023647)
COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022460)
3x4Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022510)
3x4Hyp-3Hyp-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022483)
3x4Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022948)
3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022970)
5Hyl-COL5A1(38-1838) [endoplasmic reticulum lumen]
(R-HSA-2022989)
3x4Hyp-GlcGalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268653)
COL5A1(38-1838) [extracellular region]
(R-HSA-2268703)
3x4Hyp-5Hyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268718)
3x4Hyp-GalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268664)
3x4Hyp-3Hyp-COL5A1(38-1838) [extracellular region]
(R-HSA-2268667)
GalHyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268629)
5Hyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268644)
3x4Hyp-3Hyp-5Hyl-COL5A1(38-1838) [extracellular region]
(R-HSA-2268663)
0.508
2
UniProt:P0DTC8 8
2
8 [extracellular region]
(R-COV-9755410)
8 [endoplasmic reticulum lumen]
(R-COV-9727283)
0.482
2
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