HS-GAG biosynthesis

Stable Identifier
R-HSA-2022928
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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HS-GAG biosynthesis
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Heparan sulfate (HS) and heparin (sometimes collectively called HS-GAG) chains consist of the variably sulfated repeating disaccharide units heparan (Ido-GlcNAc) or heparosan (GlcA-GlcNAc). Heparin is exclusively made in mast cells whereas HS is made by virtually every type of cell in the body. As the chain length increases, the polysaccharides can undergo modifications such as epimerisation of glucuronic acid to iduronic acid and deacetylation and sulfation of GlcNAc to form sulfated glucosamine (Stringer & Gallagher 1997, Sasisekharan & Venkataraman 2000).
Literature References
PubMed ID Title Journal Year
11102866 Heparin and heparan sulfate: biosynthesis, structure and function

Sasisekharan, R, Venkataraman, G

Curr Opin Chem Biol 2000
9251237 Heparan sulphate

Stringer, SE, Gallagher, JT

Int J Biochem Cell Biol 1997
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Events
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Event Information
Go Biological Process
heparan sulfate proteoglycan biosynthetic process (0015012)
Orthologous Events
HS-GAG biosynthesis (Bos taurus)
HS-GAG biosynthesis (Caenorhabditis elegans)
HS-GAG biosynthesis (Canis familiaris)
HS-GAG biosynthesis (Danio rerio)
HS-GAG biosynthesis (Dictyostelium discoideum)
HS-GAG biosynthesis (Drosophila melanogaster)
HS-GAG biosynthesis (Gallus gallus)
HS-GAG biosynthesis (Mus musculus)
HS-GAG biosynthesis (Rattus norvegicus)
HS-GAG biosynthesis (Sus scrofa)
HS-GAG biosynthesis (Xenopus tropicalis)
Authored
Jassal, B  (2011-12-01)
Reviewed
D'Eustachio, P  (2012-03-28)
Matthews, L  (2025-05-30)
Hill, DP  (2025-06-02)
Created
Jassal, B  (2011-12-01)
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