HS3ST1 sulfates GlcN at C3 in heparan sulfate

Stable Identifier
R-HSA-2076383
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Heparan sulfate 3-O-sulfotransferase1 (HS3ST1) transfers sulfate to the 3-OH position on glucosamine (GlcN) residues of heparan sulfate (HS) to form 3-O-sulfated HS. HS3ST1 is the rate limiting enzyme for synthesis of anticoagulant heparan sulfate. Unlike the other members of the HS3ST family, it is probably located in the Golgi lumen (Shworak et al. 1997).

Literature References
PubMed ID Title Journal Year
9346953 Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase

Shworak, NW, Liu, J, Fritze, LM, Schwartz, JJ, Zhang, L, Logeart, D, Rosenberg, RD

J Biol Chem 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity of HS3ST sulfotransferases [Golgi lumen]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created