Reactome | HS3ST1 sulfates GlcN at C3 in heparan sulfate

HS3ST1 sulfates GlcN at C3 in heparan sulfate

Stable Identifier

R-HSA-2076383

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi lumen

ReviewStatus

5/5

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HS3ST1 sulfates GlcN at C3 in heparan sulfate

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Heparan sulfate 3-O-sulfotransferase1 (HS3ST1) transfers sulfate to the 3-OH position on glucosamine (GlcN) residues of heparan sulfate (HS) to form 3-O-sulfated HS. HS3ST1 is the rate limiting enzyme for synthesis of anticoagulant heparan sulfate. Unlike the other members of the HS3ST family, it is probably located in the Golgi lumen (Shworak et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
9346953	Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase Shworak, NW, Liu, J, Fritze, LM, Schwartz, JJ, Zhang, L, Logeart, D, Rosenberg, RD	J Biol Chem	1997