NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)

Stable Identifier
R-HSA-2022860
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The bifunctional enzymes heparan sulfate N-deacetylases/N-sulfotransferases 1-4 (NDST1-4) catalyse both the N-deacetylation and the N-sulfation of N-acetylglucosamine (GlcNAc) of heparan (Dixon et al. 1995, Duncan et al. 2006, Aikawa & Esko 1999, Aikawa et al. 2001). Once GlcNAc is deacetylated to glucosamine, the NDST enzymes can sulfate it on position 2 (N).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
[heparan sulfate]-glucosamine N-sulfotransferase activity of NDSTs [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created