Reactome | NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)

NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)

Stable Identifier

R-HSA-2022860

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

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NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)

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The bifunctional enzymes heparan sulfate N-deacetylases/N-sulfotransferases 1-4 (NDST1-4) catalyse both the N-deacetylation and the N-sulfation of N-acetylglucosamine (GlcNAc) of heparan (Dixon et al. 1995, Duncan et al. 2006, Aikawa & Esko 1999, Aikawa et al. 2001). Once GlcNAc is deacetylated to glucosamine, the NDST enzymes can sulfate it on position 2 (N).

Literature References

PubMed ID	Title	Journal	Year
9915799	Molecular cloning and expression of a third member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family Esko, JD, Aikawa, J	J Biol Chem	1999
11087757	Multiple isozymes of heparan sulfate/heparin GlcNAc N-deacetylase/GlcN N-sulfotransferase. Structure and activity of the fourth member, NDST4 Tsujimoto, M, Esko, JD, Grobe, K, Aikawa, J	J Biol Chem	2001
16343444	Characterization of the N-deacetylase domain from the heparan sulfate N-deacetylase/N-sulfotransferase 2 Liu, J, Duncan, MB, Liu, M, Fox, C	Biochem Biophys Res Commun	2006
7601448	Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1 Gladwin, AJ, Dixon, MJ, Wasmuth, JJ, Scambler, PJ, Dixon, J, Loftus, SK	Genomics	1995