HS6STs sulfate GlcN at C6 in heparan sulfate/heparin

Stable Identifier
R-HSA-2076419
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Heparan-sulfate 6-O-sulfotransferases 1 and 2 (HS3ST1-2) (Habuchi et al. 1998, Habuchi et al. 2003 respectively) catalyze the transfer of sulfate to C6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. A third member HS3ST3 that may also mediate this reaction has been characterised in mouse (Habuchi et al. 2000) but remains uncharacterised in humans. It can be argued that this structure can now be called either heparan sulfate- or heparin-PG.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
heparan sulfate 6-O-sulfotransferase activity of HS6STs [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created