Some HSPGs are secreted to the plasma membrane

Stable Identifier
R-HSA-2024108
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Golgi lumen, plasma membrane
ReviewStatus
5/5
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Some HSPGs are secreted to the plasma membrane
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Depending on the nature of the core protein HS-GAGs are attached to, they will either translocate to the cell surface or be secreted into the extracellular matrix (ECM). Here, HS-GAGs are shown to translocate to the cell surface (Kjellen & Lindahl, 1991). The mechanism of transfer from the Golgi apparatus to the cell surface and beyond is unknown but most likely involves the trans-Golgi network.
Literature References
PubMed ID Title Journal Year
10716625 Heparan sulfate proteoglycans on the cell surface: versatile coordinators of cellular functions

Tumova, S, Woods, A, Couchman, JR

Int J Biochem Cell Biol 2000
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Authored
Jassal, B  (2011-12-14)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2011-12-14)
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