HS3STs sulfate GlcN at C3 in heparan sulfate

Stable Identifier
R-HSA-2076611
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Heparan sulfate 3-O-sulfotransferases (HS3ST2-6) transfer sulfate to the 3-OH position on glucosamine (GlcN) residues of heparan sulfate (HS) to form 3-O-sulfated HS (Shworak et al. 1999, Xia et al. 2002). HS3ST2-6 do not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Literature References
PubMed ID Title Journal Year
9988767 Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci

Shworak, NW, Liu, J, Petros, LM, Zhang, L, Kobayashi, M, Copeland, NG, Jenkins, NA, Rosenberg, RD

J Biol Chem 1999
9346953 Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase

Shworak, NW, Liu, J, Fritze, LM, Schwartz, JJ, Zhang, L, Logeart, D, Rosenberg, RD

J Biol Chem 1997
12138164 Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1

Xia, G, Chen, J, Tiwari, V, Ju, W, Li, JP, Malmstrom, A, Shukla, D, Liu, J

J Biol Chem 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity of HS3STs [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created