Reactome | HS3STs sulfate GlcN at C3 in heparan sulfate

HS3STs sulfate GlcN at C3 in heparan sulfate

Stable Identifier

R-HSA-2076611

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

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HS3STs sulfate GlcN at C3 in heparan sulfate

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Heparan sulfate 3-O-sulfotransferases (HS3ST2-6), associated with the Golgi membrane, transfer sulfate to the 3-OH position on glucosamine (GlcN) residues of heparan sulfate (HS) to form 3-O-sulfated HS (Shworak et al. 1999, Xia et al. 2002). HS3ST2-6 do not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate.

Literature References

PubMed ID	Title	Journal	Year
9346953	Molecular cloning and expression of mouse and human cDNAs encoding heparan sulfate D-glucosaminyl 3-O-sulfotransferase Liu, J, Rosenberg, RD, Schwartz, JJ, Fritze, LM, Zhang, L, Logeart, D, Shworak, NW	J Biol Chem	1997
9988767	Multiple isoforms of heparan sulfate D-glucosaminyl 3-O-sulfotransferase. Isolation, characterization, and expression of human cDNAs and identification of distinct genomic loci Copeland, NG, Liu, J, Kobayashi, M, Rosenberg, RD, Jenkins, NA, Zhang, L, Petros, LM, Shworak, NW	J Biol Chem	1999
12138164	Heparan sulfate 3-O-sulfotransferase isoform 5 generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1 Liu, J, Malmstrom, A, Chen, J, Shukla, D, Tiwari, V, Ju, W, Li, JP, Xia, G	J Biol Chem	2002