HS2ST1 sulfates IdoA at C2 in heparan sulfate

Stable Identifier
R-HSA-2076508
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Human heparan sulfate L-iduronyl 2-O-sulfotransferase 1 (HS2ST1) mediates the transfer of sulfate from PAPS to the C2-position of iduronate (and glucuronate with lesser preference) (Smeds et al. 2010) residues in heparan sulfate chains (Rong et al. 2000).

Literature References
PubMed ID Title Journal Year
20554947 Target selection of heparan sulfate hexuronic acid 2-O-sulfotransferase

Smeds, E, Feta, A, Kusche-Gullberg, M

Glycobiology 2010
10677367 Expression of heparan sulphate L-iduronyl 2-O-sulphotransferase in human kidney 293 cells results in increased D-glucuronyl 2-O-sulphation

Rong, J, Habuchi, H, Kimata, K, Lindahl, U, Kusche-Gullberg, M

Biochem J 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
heparan sulfate 2-O-sulfotransferase activity of HS2ST1 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created