The human gene SLC35D2 encodes the UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (UGTREL8; homolog of Fringe connection protein 1, HFRC1). It resides on the Golgi membrane where it mediates the transport of nucleotide sugars including UDP-GlcNAc into the Golgi lumen in exchange for UMP (Suda et al. 2004, Ishida et al. 2005).
Ishida, N, Miyatake, S, Sanai, Y, Kawakita, M, Aoki, K, Kuba, T
Suzuki, M, Kamiyama, S, Aoki, T, Suda, T, Kikuchi, N, Narimatsu, H, Nishihara, S, Nakayama, K, Jigami, Y
nucleotide-sugar transmembrane transporter activity of SLC35D2 [Golgi membrane]
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