SLC35D2 exchanges UDP-sugars for UMP

Stable Identifier
R-HSA-744231
Type
Reaction
Species
Homo sapiens
Compartment
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The human gene SLC35D2 encodes the UDP-N-acetylglucosamine/UDP-glucose/GDP-mannose transporter (UGTREL8; homolog of Fringe connection protein 1, HFRC1). It resides on the Golgi membrane where it mediates the transport of nucleotide sugars such as UDP-GlcNAc and UDP-glucose into the Golgi lumen in exchange for UMP (Suda et al. 2004, Ishida et al. 2005).

Literature References
PubMed ID Title Journal Year
15607426 Identification and characterization of human Golgi nucleotide sugar transporter SLC35D2, a novel member of the SLC35 nucleotide sugar transporter family

Ishida, N, Miyatake, S, Sanai, Y, Kawakita, M, Aoki, K, Kuba, T

Genomics 2005
15082721 Molecular cloning and characterization of a human multisubstrate specific nucleotide-sugar transporter homologous to Drosophila fringe connection

Suzuki, M, Kamiyama, S, Aoki, T, Suda, T, Kikuchi, N, Narimatsu, H, Nishihara, S, Nakayama, K, Jigami, Y

J Biol Chem 2004
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Participates
Catalyst Activity

nucleotide-sugar transmembrane transporter activity of SLC35D2 [Golgi membrane]

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