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ITGAL [specific granule membrane]
Stable Identifier
R-HSA-6799536
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
specific granule membrane
Synonyms
Integrin alpha-L precursor, ITAL_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of specific granule membrane proteins (Homo sapiens)
Specific granule membrane proteins [specific granule membrane] (Homo sapiens)
ITGAL [specific granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20701 ITGAL
Gene Names
ITGAL, CD11a, CD11A
Chain
signal peptide:1-25, chain:26-1170
Reference Genes
BioGPS Gene:3683 ITGAL
COSMIC (genes):ITGAL ITGAL
CTD Gene:3683 ITGAL
dbSNP Gene:3683 ITGAL
ENSEMBL:ENSG00000005844 ITGAL
ENSEMBL_homo_sapiens_GENE:ENSG00000005844.19 ITGAL
HGNC:6148 ITGAL
KEGG Gene (Homo sapiens):3683 ITGAL
Monarch:3683 ITGAL
NCBI Gene:3683 ITGAL
OMIM:153370 ITGAL
UCSC:P20701 ITGAL
Reference Transcript
RefSeq:NM_001114380.1 ITGAL
RefSeq:NM_002209.2 ITGAL
Other Identifiers
11729226_x_at
11736888_x_at
11749402_a_at
11751304_a_at
1554240_3p_a_at
1554240_PM_a_at
1554240_a_at
16817883
213475_PM_s_at
213475_s_at
3656224
3656225
3656229
3656232
3656233
3656234
3656235
3656236
3656237
3656238
3656239
3656240
3656242
3656245
3656246
3656247
3656248
3656249
3656250
3656251
3656254
3656256
3656257
3656259
3656260
3656261
3656262
3656263
3656264
3656265
3656266
3656267
3656269
3656272
3656273
3656276
3656277
3656278
3683
72013_at
7994826
A_14_P102211
A_14_P107530
A_14_P112216
A_23_P206806
GE560436
GE62722
GO:0002291
GO:0002376
GO:0005178
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006909
GO:0006954
GO:0007155
GO:0007157
GO:0007159
GO:0007160
GO:0007165
GO:0007229
GO:0008305
GO:0009897
GO:0009986
GO:0016020
GO:0016192
GO:0023052
GO:0030369
GO:0031410
GO:0033627
GO:0034687
GO:0035579
GO:0035683
GO:0043113
GO:0043226
GO:0044877
GO:0046872
GO:0048870
GO:0050839
GO:0060089
GO:0070062
GO:0098609
HMNXSV003031211
Hs.174103.1.S1_3p_a_at
Hs2.174103.2.S1_3p_x_at
ILMN_1749591
TC16000349.hg
Y00796_at
Participates
as a member of
Specific granule membrane proteins [specific granule membrane] (Homo sapiens)
Other forms of this molecule
ITGAL [plasma membrane]
Inferred To
Itgal [specific granule membrane]
(Rattus norvegicus)
if [specific granule membrane]
(Drosophila melanogaster)
ITGAL [specific granule membrane]
(Bos taurus)
ITGAL [specific granule membrane]
(Canis familiaris)
ITGAL [specific granule membrane]
(Mus musculus)
ITGAL [specific granule membrane]
(Sus scrofa)
pat-2 [specific granule membrane]
(Caenorhabditis elegans)
itgam.1 [specific granule membrane]
(Danio rerio)
Cross References
RefSeq
NP_002200.2
,
NP_001107852.1
Guide to Pharmacology - Targets
2451
OpenTargets
ENSG00000005844
ZINC - Substances
ITAL_HUMAN
ZINC - Biogenic
ITAL_HUMAN
ZINC target
P20701
PRO
P20701
PDB
1ZOP
,
1T0P
,
1MQ9
,
1RD4
,
3BQN
,
1XUO
,
3F78
,
6BXF
,
3EOA
,
5E6S
,
3E2M
,
2M3E
,
1LFA
,
6BXJ
,
5E6U
,
1CQP
,
1MQA
,
3HI6
,
4IXD
,
2K8O
,
1DGQ
,
1XDD
,
7KC6
,
3EOB
,
3M6F
,
6BXB
,
2O7N
,
1MJN
,
2ICA
,
5E6R
,
6CKB
,
7KC3
,
1ZOO
,
1XDG
,
3TCX
,
3F74
,
3BQM
,
1ZON
,
7KC5
,
3BN3
,
1MQ8
ZINC - Investigational
ITAL_HUMAN
HPA
ENSG00000005844-ITGAL
GeneCards
P20701
Ensembl
ENST00000356798
,
ENST00000358164
,
ENSP00000349252
,
ENSG00000005844
,
ENSP00000350886
Pharos - Targets
P20701
ZINC - Predictions - Purchasable
ITAL_HUMAN
HMDB Protein
HMDBP02147
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08575 PTPRC
2
PTPRC [secretory granule membrane]
(R-HSA-6806150)
PTPRC [plasma membrane]
(R-HSA-197931)
0.508
2
UniProt:P04578 env
7
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
0.462
2
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