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ITGAL [plasma membrane]
Stable Identifier
R-HSA-198013
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Integrin alpha-L precursor, ITAL_HUMAN
Locations in the PathwayBrowser
Expand all
Extracellular matrix organization (Homo sapiens)
Integrin cell surface interactions (Homo sapiens)
ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Homo sapiens)
Integrin alphaLbeta2 [plasma membrane] (Homo sapiens)
ITGAL [plasma membrane] (Homo sapiens)
LFA-1:ICAM 1-5 [plasma membrane] (Homo sapiens)
Integrin alphaLbeta2 [plasma membrane] (Homo sapiens)
ITGAL [plasma membrane] (Homo sapiens)
Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Homo sapiens)
Integrin alphaLbeta2 [plasma membrane] (Homo sapiens)
ITGAL [plasma membrane] (Homo sapiens)
Integrin alphaLbeta2:F11R [plasma membrane] (Homo sapiens)
Integrin alphaLbeta2 [plasma membrane] (Homo sapiens)
ITGAL [plasma membrane] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
RUNX3 Regulates Immune Response and Cell Migration (Homo sapiens)
ITGAL gene,(ITGA4 gene) expression is stimulated by RUNX3:CBFB (Homo sapiens)
ITGAL,(ITGA4) [plasma membrane] (Homo sapiens)
ITGAL [plasma membrane] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
Integrin alphaLbeta2 (LFA-1) binds F11R (JAM-A) (Homo sapiens)
Integrin alphaLbeta2 [plasma membrane] (Homo sapiens)
ITGAL [plasma membrane] (Homo sapiens)
Integrin alphaLbeta2:F11R [plasma membrane] (Homo sapiens)
Integrin alphaLbeta2 [plasma membrane] (Homo sapiens)
ITGAL [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell (Homo sapiens)
ICAM1-5 bind Integrin alphaLbeta2 (LFA-1) (Homo sapiens)
Integrin alphaLbeta2 [plasma membrane] (Homo sapiens)
ITGAL [plasma membrane] (Homo sapiens)
LFA-1:ICAM 1-5 [plasma membrane] (Homo sapiens)
Integrin alphaLbeta2 [plasma membrane] (Homo sapiens)
ITGAL [plasma membrane] (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of specific granule membrane proteins (Homo sapiens)
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
ITGAL [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20701 ITGAL
Gene Names
ITGAL, CD11a, CD11A
Chain
signal peptide:1-25, chain:26-1170
Reference Genes
BioGPS Gene:3683 ITGAL
COSMIC (genes):ITGAL ITGAL
CTD Gene:3683 ITGAL
dbSNP Gene:3683 ITGAL
ENSEMBL:ENSG00000005844 ITGAL
HGNC:6148 ITGAL
KEGG:hsa:3683 ITGAL
Monarch:3683 ITGAL
NCBI Gene:3683 ITGAL
OMIM:153370 ITGAL
UCSC:P20701 ITGAL
Reference Transcript
RefSeq:NM_002209.2 ITGAL
RefSeq:NM_001114380.1 ITGAL
Other Identifiers
11729226_x_at
11736888_x_at
11749402_a_at
11751304_a_at
1554240_3p_a_at
1554240_PM_a_at
1554240_a_at
16817883
16817920
213475_PM_s_at
213475_s_at
3656224
3656225
3656226
3656227
3656228
3656229
3656232
3656233
3656234
3656235
3656236
3656237
3656238
3656239
3656240
3656241
3656242
3656243
3656245
3656246
3656247
3656248
3656249
3656250
3656251
3656254
3656255
3656256
3656257
3656259
3656260
3656261
3656262
3656263
3656264
3656265
3656266
3656267
3656268
3656269
3656271
3656272
3656273
3656276
3656277
3656278
3656280
3683
72013_at
7994826
A_14_P102211
A_14_P107530
A_14_P112216
A_14_P200425
A_23_P206806
GE560436
GE62722
GO:0002291
GO:0002376
GO:0005178
GO:0005515
GO:0005886
GO:0006909
GO:0006954
GO:0007155
GO:0007157
GO:0007159
GO:0007160
GO:0007165
GO:0007229
GO:0008305
GO:0009897
GO:0009986
GO:0016020
GO:0016192
GO:0030369
GO:0033627
GO:0034687
GO:0035579
GO:0035683
GO:0043113
GO:0043226
GO:0044877
GO:0046872
GO:0048870
GO:0050839
GO:0060089
GO:0070062
GO:0098609
HMNXSV003031211
Hs.174103.1.S1_3p_a_at
Hs2.174103.2.S1_3p_x_at
ILMN_1749591
TC16000349.hg
TC16001488.hg
Y00796_at
Participates
as a member of
ITGAL,(ITGA4) [plasma membrane] (Homo sapiens)
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
as a component of
Integrin alphaLbeta2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
ITGAL [specific granule membrane]
Inferred To
ITGAL [plasma membrane]
(Bos taurus)
ITGAL [plasma membrane]
(Canis familiaris)
ITGAL [plasma membrane]
(Mus musculus)
ITGAL [plasma membrane]
(Sus scrofa)
Itgal [plasma membrane]
(Rattus norvegicus)
if [plasma membrane]
(Drosophila melanogaster)
itgam.1 [plasma membrane]
(Danio rerio)
pat-2 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_002200.2
,
NP_001107852.1
Guide to Pharmacology - Targets
2451
OpenTargets
ENSG00000005844
ENSEMBL
ENSP00000350886
,
ENST00000358164
,
ENSP00000349252
,
ENST00000356798
ZINC - Substances
ITAL_HUMAN
ZINC - Biogenic
ITAL_HUMAN
ZINC target
P20701
PRO
P20701
PDB
2O7N
,
3HI6
,
6BXF
,
3BQM
,
1CQP
,
5E6S
,
4IXD
,
3F74
,
6BXB
,
1MJN
,
3M6F
,
5E6R
,
2ICA
,
1LFA
,
1ZOO
,
1ZON
,
1ZOP
,
2K8O
,
1RD4
,
7KC5
,
3EOB
,
3E2M
,
3F78
,
3EOA
,
3BN3
,
3TCX
,
3BQN
,
1MQA
,
1DGQ
,
1XDG
,
2M3E
,
5E6U
,
6BXJ
,
7KC3
,
7KC6
,
1XUO
,
6CKB
,
1MQ9
,
1MQ8
,
1XDD
,
1T0P
ZINC - Investigational
ITAL_HUMAN
HPA
ENSG00000005844-ITGAL
Pharos - Targets
P20701
ZINC - Predictions - Purchasable
ITAL_HUMAN
HMDB Protein
HMDBP02147
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08575 PTPRC
2
PTPRC [plasma membrane]
(R-HSA-197931)
PTPRC [secretory granule membrane]
(R-HSA-6806150)
0.508
2
UniProt:P04578 env
7
ENV [viral envelope]
(R-HIV-173439)
Surface protein gp120 [viral envelope]
(R-HIV-171211)
Transmembrane protein gp41 [viral envelope]
(R-HIV-171195)
Envelope glycoprotein gp160 [endoplasmic reticulum membrane]
(R-HIV-189343)
Glycosylated Envelope glycoprotein gp160 [Golgi membrane]
(R-HIV-3149443)
Transmembrane protein gp41 (P04578) [cytosol]
(R-HIV-189359)
Surface protein gp120 (P04578) [cytosol]
(R-HIV-189269)
0.462
2
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