EGFR binds EGF ligand

Stable Identifier
R-HSA-177942
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The prototypic receptor tyrosine kinase (RTK) EGFR is composed of 3 major domains; an extracellular domain linked via a single membrane-spanning domain to a cytoplasmic domain. EGF binds to the extracellular domain from where the signal is transmitted to the cytoplasmic domain.

Literature References
PubMed ID Title Journal Year
8639530 Activation of epidermal growth factor receptor by epidermal growth factor

Sherrill, JM, Kyte, J

Biochemistry 1996
Participants
Participant Of
This event is regulated
Negatively by
Orthologous Events
Authored
Reviewed
Created