EGFR binds EGF ligand

Stable Identifier
R-HSA-177942
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
ReviewStatus
5/5
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EGFR binds EGF ligand
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The prototypic receptor tyrosine kinase (RTK) EGFR is composed of 3 major domains; an extracellular domain linked via a single membrane-spanning domain to a cytoplasmic domain. EGF binds to the extracellular domain from where the signal is transmitted to the cytoplasmic domain.
Literature References
PubMed ID Title Journal Year
8639530 Activation of epidermal growth factor receptor by epidermal growth factor

Kyte, J, Sherrill, JM

Biochemistry 1996
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
LRIG1 [plasma membrane] (Homo sapiens)
Orthologous Events
EGFR binds EGF ligand (Bos taurus)
EGFR binds EGF ligand (Caenorhabditis elegans)
EGFR binds EGF ligand (Canis familiaris)
EGFR binds EGF ligand (Danio rerio)
EGFR binds EGF ligand (Drosophila melanogaster)
EGFR binds EGF ligand (Gallus gallus)
EGFR binds EGF ligand (Mus musculus)
EGFR binds EGF ligand (Rattus norvegicus)
EGFR binds EGF ligand (Sus scrofa)
EGFR binds EGF ligand (Xenopus tropicalis)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Muthuswamy, S  (2007-02-17)
Created
Jassal, B  (2006-04-11)
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