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GGC-RAB4A [cytoplasmic vesicle membrane]
Stable Identifier
R-HSA-1458526
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane
Synonyms
Ras-related protein Rab-4A, RAB4A_HUMAN
Locations in the PathwayBrowser
Expand all
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Rab regulation of trafficking (Homo sapiens)
TBC/RABGAPs (Homo sapiens)
TBC1D16 accelerates GTP hydrolysis by RAB4A (Homo sapiens)
GGC-RAB4A:GDP [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB4A [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB4A:GTP [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB4A [cytoplasmic vesicle membrane] (Homo sapiens)
Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
RAB4A:GTP binds KIF3 and activates KIF3 (Homo sapiens)
GGC-RAB4A:GTP [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB4A [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB4A:GTP:KIF3:microtubule [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB4A:GTP [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB4A [cytoplasmic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P20338 RAB4A
Gene Names
RAB4A, RAB4
Chain
chain:1-218
Reference Genes
BioGPS Gene:5867 RAB4A
COSMIC (genes):RAB4A RAB4A
CTD Gene:5867 RAB4A
dbSNP Gene:5867 RAB4A
ENSEMBL:ENSG00000168118 RAB4A
HGNC:9781 RAB4A
KEGG:hsa:5867 RAB4A
Monarch:5867 RAB4A
NCBI Gene:5867 RAB4A
OMIM:179511 RAB4A
UCSC:P20338 RAB4A
Reference Transcript
RefSeq:NM_004578.3 RAB4A
RefSeq:NM_001271998.1 RAB4A
Other Identifiers
11721301_a_at
11743887_s_at
11758844_at
16678536
1685_at
1686_g_at
203581_PM_at
203581_at
203582_PM_s_at
203582_s_at
206272_PM_at
206272_at
2384563
2384564
2384565
2384567
2384570
2384571
2384572
2384576
2384577
2384578
2384579
2384580
2384581
2384583
2384584
2384585
2384586
2384587
2384588
2384589
2384590
39244_at
5867
621_at
7910398
A_14_P119800
A_14_P125512
A_23_P217938
A_23_P369919
A_24_P122682
GE57900
GE80410
GO:0002376
GO:0003824
GO:0003924
GO:0003925
GO:0005515
GO:0005525
GO:0005737
GO:0005768
GO:0007264
GO:0015031
GO:0016020
GO:0016192
GO:0016787
GO:0019003
GO:0019882
GO:0030100
GO:0030659
GO:0031410
GO:0031901
GO:0031982
GO:0032482
GO:0032593
GO:0043226
GO:0048471
GO:0055038
GO:0070062
GO:0098772
GO:0098837
GO:0098968
GO:0098978
GO:0099003
HMNXSV003016611
HMNXSV003039554
ILMN_1677824
ILMN_1718832
M28211_at
PH_hs_0026610
TC01001900.hg
TC01005092.hg
X82554_rna1_at
g12803248_3p_at
g4759001_3p_a_at
g5730062_3p_at
Participates
as a component of
GGC-RAB4A:GDP [cytoplasmic vesicle membrane] (Homo sapiens)
GGC-RAB4A:GTP [cytoplasmic vesicle membrane] (Homo sapiens)
Other forms of this molecule
GGC-RAB4A [cytosol]
RAB4A [cytosol]
RAB4A [early endosome membrane]
GGC-RAB4A [recycling endosome membrane]
Inferred To
Rab4 [cytoplasmic vesicle membrane]
(Drosophila melanogaster)
RAB4A [cytoplasmic vesicle membrane]
(Canis familiaris)
RAB4A [cytoplasmic vesicle membrane]
(Sus scrofa)
GGC-RAB4A [cytoplasmic vesicle membrane]
(Bos taurus)
GGC-RAB4A [cytoplasmic vesicle membrane]
(Danio rerio)
GGC-RAB4A [cytoplasmic vesicle membrane]
(Dictyostelium discoideum)
GGC-RAB4A [cytoplasmic vesicle membrane]
(Gallus gallus)
GGC-RAB4A [cytoplasmic vesicle membrane]
(Mus musculus)
GGC-RAB4A [cytoplasmic vesicle membrane]
(Rattus norvegicus)
Modified Residues
Name
S-geranylgeranyl-L-cysteine at 216
Coordinate
216
PsiMod Name
S-geranylgeranyl-L-cysteine [MOD:00113]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.
Name
S-geranylgeranyl-L-cysteine at 218
Coordinate
218
PsiMod Name
S-geranylgeranyl-L-cysteine [MOD:00113]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.
Cross References
ENSEMBL
ENST00000366690
,
ENSP00000355651
OpenTargets
ENSG00000168118
HPA
ENSG00000168118-RAB4A
PRO
P20338
Pharos - Targets
P20338
PDB
1YU9
,
2BME
,
2BMD
,
1Z0K
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00471 EXOC5
2
EXOC5 [cytosol]
(R-HSA-265045)
EXOC5 [cytosol]
(R-HSA-5623383)
0.718
6
UniProt:Q9H1K0 RBSN
1
ZFYVE20 [endosome membrane]
(R-HSA-188000)
0.659
4
GTP [ChEBI:15996]
7
GTP [cilium]
(R-ALL-5617813)
GTP [early endosome membrane]
(R-ALL-2130170)
GTP [lysosomal membrane]
(R-ALL-2213216)
GTP [platelet dense granule lumen]
(R-ALL-114625)
GTP [cytoplasmic vesicle membrane]
(R-ALL-1996291)
GTP [ER to Golgi transport vesicle membrane]
(R-ALL-983318)
GTP [Golgi membrane]
(R-ALL-1806221)
0.623
3
UniProt:Q96JA1 LRIG1
2
Ub-LRIG1 [plasma membrane]
(R-HSA-8875434)
LRIG1 [plasma membrane]
(R-HSA-197745)
0.527
2
UniProt:Q92597 NDRG1
1
NDRG1 [cytosol]
(R-HSA-5628834)
0.463
2
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