Reactome | GGC-RAB4A [cytoplasmic vesicle membrane]

GGC-RAB4A [cytoplasmic vesicle membrane]

Stable Identifier

R-HSA-1458526

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytoplasmic vesicle membrane

Synonyms

Ras-related protein Rab-4A, RAB4A_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P20338 RAB4A

Gene Names

RAB4A, RAB4

Chain

chain:1-218

Reference Genes

BioGPS Gene:5867 RAB4A

COSMIC (genes):RAB4A RAB4A

CTD Gene:5867 RAB4A

dbSNP Gene:5867 RAB4A

ENSEMBL:ENSG00000168118 RAB4A

ENSEMBL:ENSG00000168118.12 RAB4A

HGNC:9781 RAB4A

KEGG Gene (Homo sapiens):5867 RAB4A

Monarch:5867 RAB4A

NCBI Gene:5867 RAB4A

OMIM:179511 RAB4A

UCSC:P20338 RAB4A

Reference Transcript

Other Identifiers

11721301_a_at

11743887_s_at

11758844_at

16678536

1685_at

1686_g_at

203581_PM_at

203581_at

203582_PM_s_at

203582_s_at

206272_PM_at

206272_at

2384563

2384564

2384565

2384567

2384570

2384576

2384577

2384578

2384579

2384580

2384581

2384583

2384584

2384585

2384586

2384587

2384588

2384589

2384590

39244_at

5867

621_at

7910398

A_14_P119800

A_14_P125512

A_23_P217938

A_23_P369919

A_24_P122682

GE57900

GE80410

GO:0000166

GO:0002376

GO:0003824

GO:0003924

GO:0003925

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005737

GO:0005768

GO:0005886

GO:0007264

GO:0012505

GO:0015031

GO:0016020

GO:0016192

GO:0016787

GO:0019003

GO:0019882

GO:0023052

GO:0030100

GO:0030659

GO:0031410

GO:0031901

GO:0031982

GO:0032482

GO:0043226

GO:0048471

GO:0055038

GO:0070062

GO:0098772

GO:0098837

HMNXSV003016611

HMNXSV003039554

ILMN_1677824

ILMN_1718832

M28211_at

PH_hs_0026610

TC01001900.hg

TC01005092.hg

X82554_rna1_at

g12803248_3p_at

g4759001_3p_a_at

g5730062_3p_at

Participates

as a component of

Other forms of this molecule

GGC-RAB4A [cytosol]

RAB4A [cytosol]

RAB4A [early endosome membrane]

GGC-RAB4A [recycling endosome membrane]

Inferred To

Rab4 [cytoplasmic vesicle membrane] (Drosophila melanogaster)

RAB4A [cytoplasmic vesicle membrane] (Sus scrofa)

GGC-RAB4A [cytoplasmic vesicle membrane] (Bos taurus)

GGC-RAB4A [cytoplasmic vesicle membrane] (Canis familiaris)

GGC-RAB4A [cytoplasmic vesicle membrane] (Danio rerio)

GGC-RAB4A [cytoplasmic vesicle membrane] (Dictyostelium discoideum)

GGC-RAB4A [cytoplasmic vesicle membrane] (Gallus gallus)

GGC-RAB4A [cytoplasmic vesicle membrane] (Mus musculus)

GGC-RAB4A [cytoplasmic vesicle membrane] (Rattus norvegicus)

Modified Residues

Name

S-geranylgeranyl-L-cysteine at 216

Coordinate

216

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Name

S-geranylgeranyl-L-cysteine at 218

Coordinate

218

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Cross References

RefSeq

NP_001258927.1, NP_004569.2

OpenTargets

ENSG00000168118

IntEnz

3.6.5.2

HPA

ENSG00000168118-RAB4A

GeneCards

P20338

Ensembl

ENSG00000168118, ENSP00000355651, ENST00000366690

PRO

P20338

Pharos - Targets

P20338

PDB

2BME, 2BMD, 1Z0K, 1YU9

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.718	6
UniProt:Q9H1K0 RBSN	1	ZFYVE20 [endosome membrane] (R-HSA-188000)	0.659	4
GTP [ChEBI:15996]	7	GTP [cilium] (R-ALL-5617813) GTP [early endosome membrane] (R-ALL-2130170) GTP [lysosomal membrane] (R-ALL-2213216) GTP [platelet dense granule lumen] (R-ALL-114625) GTP [cytoplasmic vesicle membrane] (R-ALL-1996291) GTP [ER to Golgi transport vesicle membrane] (R-ALL-983318) GTP [Golgi membrane] (R-ALL-1806221)	0.623	3
UniProt:Q92597 NDRG1	1	NDRG1 [cytosol] (R-HSA-5628834)	0.463	2